Kannel W B
J Am Geriatr Soc. 1986 Jan;34(1):27-36. doi: 10.1111/j.1532-5415.1986.tb06336.x.
Cardiovascular disease, so common in the elderly, has become an urgent public health concern. Major contributing factors include hypertension, dyslipidemia, impaired glucose tolerance, physical indolence, and cigarette smoking. Diet plays a major role in atherogenesis by its influence in blood lipids, blood pressure, and glucose tolerance, although its impact in the elderly is speculative owing to a paucity of direct evidence. But a rationale exists. Most cardiovascular risk factors are more prevalent in the elderly than in the young adult. The rise in blood pressure and blood lipids with advancing age is not inevitable. Diet may contribute to hypertension through an excess of calories, saturated fat, cholesterol, or salt and a deficiency of potassium, calcium, and magnesium. Antiatherogenic diets low in saturated fat and cholesterol, rich in fiber, and with substitution of polyunsaturated fat and restricted calories tend to normalize serum lipids and to cause lesions to involute. Emphasis on vegetable protein and fiber-rich food has merit because they provide more fiber, polyunsaturated fatty acids, magnesium, selenium, complex carbohydrate, potassium, and copper, and less cholesterol, saturated fat, and sodium. The recommended fat-modified diets are adequate in protein, vitamins, and minerals and need not be deficient in any nutrient or economically nonfeasible. The accelerating decline in cardiovascular mortality, which has included the elderly, indicates that such disease is controllable and not inevitable, even in the elderly. The decrease has occurred concurrently with reduced consumption of saturated fat and cholesterol, increased use of vegetable oils, and improved levels of cardiovascular risk factors.
心血管疾病在老年人中极为常见,已成为亟待解决的公共卫生问题。主要促成因素包括高血压、血脂异常、糖耐量受损、身体怠惰和吸烟。饮食通过对血脂、血压和糖耐量的影响在动脉粥样硬化形成过程中起主要作用,不过由于缺乏直接证据,其对老年人的影响仍具推测性。但这是有理论依据的。多数心血管危险因素在老年人中比在年轻人中更为普遍。血压和血脂随年龄增长而升高并非不可避免。饮食中热量、饱和脂肪、胆固醇或盐过量,以及钾、钙和镁缺乏,可能导致高血压。低饱和脂肪和胆固醇、富含纤维、用多不饱和脂肪替代且热量受限的抗动脉粥样硬化饮食往往能使血脂正常化,并使病变消退。强调植物蛋白和富含纤维的食物是有道理的,因为它们能提供更多纤维、多不饱和脂肪酸、镁、硒、复合碳水化合物、钾和铜,而胆固醇、饱和脂肪和钠含量较低。推荐的脂肪改良饮食蛋白质、维生素和矿物质含量充足,不必缺乏任何营养素,也不会在经济上不可行。包括老年人在内的心血管疾病死亡率加速下降,表明这种疾病是可控的,并非不可避免,即使在老年人中也是如此。这种下降与饱和脂肪和胆固醇摄入量减少、植物油使用增加以及心血管危险因素水平改善同时发生。