Yokohama Municipal Citizen's Hospital, Yokohama, Japan.
Yokohama City University Medical Center, Yokohama, Japan.
PLoS One. 2022 Feb 1;17(2):e0263327. doi: 10.1371/journal.pone.0263327. eCollection 2022.
Rapid screening and diagnosis of coronavirus disease 2019 in the emergency department is important for controlling infections. When polymerase chain reaction tests cannot be rapidly performed, rapid antigen testing is often used, albeit with insufficient sensitivity. Therefore, we evaluated the diagnostic accuracy of combining rapid antigen and antibody test results. This was a retrospective review of patients who visited our emergency department between February and May 2021 and underwent rapid antigen, immunoglobulin G antibody, and reverse transcription-polymerase chain reaction tests. The study included 1,070 patients, of whom 56 (5.2%) tested positive on reverse transcription-polymerase chain reaction. The sensitivity, specificity, and area under the curve of rapid antigen testing were 73.7%, 100.0%, and 0.87, respectively. The combined rapid antigen and antibody test result had improved diagnostic accuracy, with 91.2% sensitivity, 97.9% specificity, and an area under the curve of 0.95. The results of the rapid antigen and antibody tests could be combined as a reliable alternative to reverse transcription-polymerase chain reaction.
在急诊科快速筛查和诊断 2019 年冠状病毒病对于控制感染很重要。当聚合酶链反应检测无法快速进行时，通常会使用快速抗原检测，但敏感性不足。因此，我们评估了快速抗原和抗体检测结果相结合的诊断准确性。这是对 2021 年 2 月至 5 月期间在我院急诊科就诊并接受快速抗原、免疫球蛋白 G 抗体和逆转录聚合酶链反应检测的患者进行的回顾性研究。该研究共纳入 1070 例患者，其中 56 例（5.2%）经逆转录聚合酶链反应检测阳性。快速抗原检测的敏感性、特异性和曲线下面积分别为 73.7%、100.0%和 0.87。联合快速抗原和抗体检测结果可提高诊断准确性，敏感性为 91.2%，特异性为 97.9%，曲线下面积为 0.95。快速抗原和抗体检测的结果可结合作为逆转录聚合酶链反应的可靠替代方法。
