University Basel Hospital, Department of Clinical Research, Evidence-based Insurance Medicine (EbIM), Research & Education, Switzerland.
Saarland University, Department of Experimental Neuropsychology, Saarbrücken, Germany.
Int J Psychophysiol. 2022 Apr;174:1-8. doi: 10.1016/j.ijpsycho.2022.01.013. Epub 2022 Jan 29.
Previous studies were not able to show that presentation of change stimuli leads to dishabituation of the auditory evoked potential (AEP) component N1 for repeated stimuli. However, these change stimuli were usually themselves repeatedly presented. Here, we tested whether the presentation of non-repeating distractor stimuli ('novels') would lead to N1 dishabituation. The study sample consisted of 18 healthy participants who had to identify auditory target stimuli (´targets´) among repeated standard stimuli and rare novels. AEPs to standards were separately averaged, depending on the preceding stimulus (standards after standards, standards after targets, and standards after novels) and were compared by F statistics and Bayesian t-test. Moreover, N1 repetition effects within recording blocks were analyzed in single trial analyses. The analyses showed that targets elicited significantly larger N1 amplitudes than standards and standards elicited larger N1 amplitudes than novels. In contrast, the N1 amplitude to standards did not vary with the preceding stimulus. The single trial analyses revealed significant, but similar N1 amplitude decreases within the recording blocks for all standards. The current study revealed no evidence for N1 dishabituation, as the N1 amplitude for standards after novels was not increased as compared to the N1 for standards after standards. Thus, stimulus variation had no impact on the N1 of repeated standards, as also suggested by the single trial analyses. The lack of N1 dishabituation is at odds with the assumption that the N1 amplitude decrease after repeated stimulation results from habituation.
先前的研究未能表明呈现变化刺激会导致听觉诱发电位 (AEP) 成分 N1 对重复刺激的习惯化。然而，这些变化刺激通常本身是重复呈现的。在这里，我们测试了呈现非重复干扰刺激（“新颖刺激”）是否会导致 N1 习惯化。研究样本包括 18 名健康参与者，他们必须在重复的标准刺激和罕见的新颖刺激中识别听觉目标刺激（“目标”）。根据先前的刺激（标准后标准、标准后目标和标准后新颖刺激）分别对 AEP 进行平均，并通过 F 统计和贝叶斯 t 检验进行比较。此外，还在单试分析中分析了记录块内的 N1 重复效应。分析表明，目标比标准引起的 N1 振幅明显更大，而标准比新颖刺激引起的 N1 振幅更大。相比之下，标准的 N1 振幅与先前的刺激无关。单试分析显示，所有标准的记录块内 N1 振幅都有显著但相似的降低。本研究没有发现 N1 习惯化的证据，因为与标准后标准的 N1 相比，新颖刺激后标准的 N1 振幅没有增加。因此，刺激变化对重复标准的 N1 没有影响，单试分析也表明了这一点。缺乏 N1 习惯化与 N1 振幅在重复刺激后减小是由于习惯化的假设相矛盾。
