Wicomb W N, Cooper D K, Novitzky D
Transplantation. 1986 Jan;41(1):29-33. doi: 10.1097/00007890-198601000-00005.
The effects of the agonal period and subsequent donor management on renal slice function, using the K+ - Na+ ratio, have been studied in the pig. Brain ischaemia or death resulted in a reduction in renal slice function, whether the pig was maintained normovolemic or hypovolemic by i.v. fluid and dobutamine therapy. This deterioration in function was, however, reversed or prevented by a period of therapy with thyroxine (T3), insulin, and cortisol. A period of 24 hr storage of the kidney slice in a low ionic strength solution in ice resulted in a further deterioration in slice function in all groups studied.
利用钾离子-钠离子比率，对猪的濒死期及随后的供体管理对肾切片功能的影响进行了研究。脑缺血或死亡导致肾切片功能降低，无论猪通过静脉输液和多巴酚丁胺治疗维持正常血容量还是低血容量。然而，通过一段时间的甲状腺素（T3）、胰岛素和皮质醇治疗，这种功能恶化得以逆转或预防。在冰浴的低离子强度溶液中对肾切片进行24小时储存，导致所有研究组的切片功能进一步恶化。
