Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center, No 17, YongWaiZheng Street, DongHu District, Nanchang, 330006, Jiangxi, People's Republic of China.
BMC Ophthalmol. 2022 Feb 2;22(1):49. doi: 10.1186/s12886-021-02228-3.
To explore functional connectivity density (FCD) values of brain areas in children with strabismus and amblyopia (SA) based on blood oxygen level-dependent (BOLD) signals.
This study recruited 26 children (14 male, 12 females) with SA and 26 healthy children (14 male, 12 female) as healthy controls (HCs). Both groups matched in age, gender, educational level and socioeconomic background. While resting, all participants underwent fMRI scanning and global FCD (gFCD) and local FCD (lFCD) values were calculated. Receiver operating characteristic (ROC) curves were created to investigate whether there was a significant difference between children with SA and healthy controls.
When compared with healthy controls, children with SA had significantly lower gFCD values in the right cerebellum, left putamen, and right superior frontal gyrus; however, the same metrics showed opposite changes in the right angular gyrus, left middle cingulate gyrus, left angular gyrus, right superior parietal gyrus, and right middle frontal gyrus. In children with SA, lFCD values were found to be remarkably decreased in regions of the middle right temporal pole, right cerebellum, left putamen, left hippocampus, right hippocampus, left thalamus, left cerebellum; values were increased in the right superior parietal gyrus as compared with healthy controls.
We noted abnormal neural connectivity in some brain areas of children with SA; detailing such connectivity aberrations is useful in exploring the pathophysiology of SA and providing useful information for future clinical management.
基于血氧水平依赖（BOLD）信号，探讨斜视性弱视（SA）儿童脑区功能连接密度（FCD）值。
本研究纳入 26 名（14 名男性，12 名女性）SA 儿童和 26 名健康儿童（14 名男性，12 名女性）作为健康对照组（HCs）。两组在年龄、性别、教育程度和社会经济背景方面相匹配。所有参与者在休息时均接受 fMRI 扫描，并计算全脑 FCD（gFCD）和局部 FCD（lFCD）值。绘制受试者工作特征（ROC）曲线，以探讨 SA 儿童与健康对照组之间是否存在显著差异。
与健康对照组相比，SA 儿童右侧小脑、左侧壳核和右侧额上回的 gFCD 值显著降低；然而，同一指标在右侧角回、左侧扣带回、左侧角回、右侧顶上回和右侧额中回显示出相反的变化。在 SA 儿童中，发现右侧颞中回、右侧小脑、左侧壳核、左侧海马体、右侧海马体、左侧丘脑、左侧小脑的 lFCD 值显著降低；与健康对照组相比，右侧顶上回的 lFCD 值增加。
我们注意到 SA 儿童一些脑区存在异常神经连接；详细描述这种连接异常有助于探索 SA 的病理生理学，并为未来的临床管理提供有用信息。
