From the Pediatric Department (Abdelhamed), Faculty of Medicine, Ain Shams University; Pediatric Department (Salah), Faculty of Medicine, Kafrelsheikh University, Kafr Elsheikh; from the Diet & Patient Meal Services (Alqudsi), International Medical Center, Jeddah, Kingdom of Saudi Arabia; From the Medicine Department (Jan), Ibn Sina National College for Medical Studies; from the Clinical Nutrition Department (Alahdal), from the Nutrition and Food Science Department (Alfaifi), from the Clinical Nutrition Department (Jafar), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia; from the Pediatric Department (Alyahyawi), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Saudi Med J. 2022 Feb;43(2):161-168. doi: 10.15537/smj.2022.43.2.20210720.
To evaluated obesity-related morbidity prevalence among overweight/obese children and adolescents in Saudi Arabia, adiposity indicators and insulin resistance as obesity-related morbidity predictors.
We enrolled 318 overweight/obese children attending a Pediatric Endocrinology Clinic at King Abdulaziz University Hospital, Saudi Arabia, aged 2-20 years in this retrospective cross-sectional study from September 2019 to March 2021. All children had nutritional obesity, and their body mass index (BMI) standard deviation score was higher than one standard deviation score above the mean for their age and gender. Clinical adiposity indices including BMI, waist circumference (WC), waist-hip ratio (WHR), and bioimpedance analysis (BIA) of body composition were assessed. Biochemical testing of insulin resistance through homeostasis model assessment for insulin resistance and fasting insulin was performed, along with receiver operating curve analysis to obtain optimal cut-off points for obesity-related morbidity.
Obesity related morbidity was found in 61.9%, whereas insulin resistance was detected among 64.7% of the patients. Body mass index standard deviation score, WC, BAI of body composition-derived body fat, homeostasis model assessment for insulin resistance, and fasting insulin are significant obesity-related morbidity predictors, and the cut-off points were established.
Obesity-related morbidity is widely prevalent among obese children and insulin resistance is a key factor in its prediction. Clinical adiposity indices, given their accuracy and practicability, are important predictors of obesity-related morbidity.
评估沙特超重/肥胖儿童和青少年肥胖相关发病率的流行情况，评估肥胖相关发病率的预测因子，包括肥胖指标和胰岛素抵抗。
我们对 2019 年 9 月至 2021 年 3 月期间在沙特阿拉伯阿卜杜勒阿齐兹国王大学医院儿科内分泌科就诊的 318 名超重/肥胖儿童进行了回顾性横断面研究，这些儿童均为营养性肥胖，其体重指数（BMI）标准差评分高于其年龄和性别平均值一个标准差以上。评估了临床肥胖指标，包括 BMI、腰围（WC）、腰臀比（WHR）和身体成分的生物阻抗分析（BIA）。通过稳态模型评估胰岛素抵抗和空腹胰岛素进行了胰岛素抵抗的生化检测，并进行了接收者操作曲线分析，以获得肥胖相关发病率的最佳截断值。
发现肥胖相关发病率为 61.9%，而患者中有 64.7%存在胰岛素抵抗。BMI 标准差评分、WC、身体成分衍生体脂的 BIA、稳态模型评估胰岛素抵抗和空腹胰岛素是肥胖相关发病率的重要预测因子，并且确定了截断值。
肥胖相关发病率在肥胖儿童中广泛存在，而胰岛素抵抗是其预测的关键因素。临床肥胖指标具有准确性和实用性，是肥胖相关发病率的重要预测因子。
