Kathak Rahanuma Raihanu, Sumon Abu Hasan, Molla Noyan Hossain, Hasan Mahmudul, Miah Rakib, Tuba Humaira Rashid, Habib Ahsan, Ali Nurshad
Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
Sci Rep. 2022 Feb 2;12(1):1711. doi: 10.1038/s41598-022-05766-y.
Dyslipidemia, a major contributor to cardiovascular diseases, is rapidly increasing in Asian countries including Bangladesh. In addition to the cardiovascular system, abnormal lipid levels are also known to cause complications in renal and hepatic systems. The data regarding dyslipidemia and its relationship with liver enzymes are scarce for the Bangladeshi population. Therefore, this study was conducted to estimate the prevalence of dyslipidemia and determine the relationship between lipid profile and liver enzymes in Bangladeshi adults. A total of 405 participants (318 males and 87 females) were enrolled in the study. Serum levels of TG, TC, LDL, HDL and liver enzymes including ALT, AST, GGT and ALP were analyzed using standard methods. Dyslipidemia and liver function tests abnormalities were defined according to the international standard guidelines. The association between elevated lipid profile markers and liver enzyme abnormalities was assessed by logistic regression analysis. Overall, the prevalence of elevated TG, TC, LDL and low HDL were 30.9%, 23.7%, 26.2% and 78.8%, respectively. On the other hand, the prevalence of elevated liver enzymes ALT, AST, GGT and ALP were 18.8%, 21.6%, 12.9% and 21.9%, respectively. Dyslipidemia and liver enzyme abnormalities were higher in diabetic and hypertensive participants than in the healthy participants. About 61% of participants with dyslipidemia had at least one or more elevated liver enzymes. In regression analysis, an independent association was observed between serum GGT and all lipid components. In conclusion, a high prevalence of dyslipidemia and liver enzyme abnormalities were observed among the study participants. Of the four liver enzymes, the serum levels of GGT showed an independent association with all lipid components. Moreover, this study indicates that subjects with dyslipidemia often have a higher chance of having liver diseases than subjects with no dyslipidemia. However, large-scale prospective studies are needed to understand the underlying mechanisms of lipid-induced hepatic dysfunction in the Bangladeshi population.
血脂异常是心血管疾病的主要成因之一，在包括孟加拉国在内的亚洲国家，其发病率正在迅速上升。除心血管系统外，脂质水平异常还会引发肾脏和肝脏系统的并发症。孟加拉国人群中关于血脂异常及其与肝酶关系的数据十分匮乏。因此，本研究旨在评估孟加拉国成年人血脂异常的患病率，并确定血脂谱与肝酶之间的关系。共有405名参与者（318名男性和87名女性）纳入本研究。采用标准方法分析血清甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）以及肝酶（包括谷丙转氨酶（ALT）、谷草转氨酶（AST）、γ-谷氨酰转肽酶（GGT）和碱性磷酸酶（ALP））的水平。血脂异常和肝功能检查异常依据国际标准指南进行定义。通过逻辑回归分析评估血脂谱标志物升高与肝酶异常之间的关联。总体而言，TG、TC、LDL升高以及HDL降低的患病率分别为30.9%、23.7%、26.2%和78.8%。另一方面，ALT、AST、GGT和ALP升高的患病率分别为18.8%、21.6%、12.9%和21.9%。糖尿病和高血压参与者的血脂异常和肝酶异常情况高于健康参与者。约61%的血脂异常参与者至少有一种或多种肝酶升高。在回归分析中，观察到血清GGT与所有脂质成分之间存在独立关联。总之，在研究参与者中观察到血脂异常和肝酶异常的高患病率。在四种肝酶中，血清GGT水平与所有脂质成分存在独立关联。此外，本研究表明，与无血脂异常的受试者相比，血脂异常的受试者患肝病的几率通常更高。然而，需要开展大规模前瞻性研究以了解孟加拉国人群中脂质诱导肝功能障碍的潜在机制。
