Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
Sci Rep. 2021 Oct 29;11(1):21339. doi: 10.1038/s41598-021-00839-w.
Preeclampsia is a multi-organ system disorder of pregnancy and is responsible for a significant rate of maternal morbidity and mortality worldwide. In Bangladesh, a large number of obstetric deaths occur every year but the exact reasons are not well investigated. The data regarding preeclampsia and its associated risk factors are scarce or limited in pregnant women in Bangladesh. Therefore, we aimed to conduct a cross-sectional study to estimate the prevalence of preeclampsia and identify the possible risk factors in a pregnant women cohort in Bangladesh. In this cross-sectional study, a total of 111 participants were enrolled and asked to include their anthropometric, socio-demographic, and other related lifestyle information in a standard questionnaire form. Blood samples were also collected from each participant to analyze serum levels of lipid profile, liver enzymes, uric acid, and creatinine by using standard methods. Logistic regression analysis was performed to identify the factors associated with preeclampsia. The overall prevalence of preeclampsia was 14.4%. About 10% of the pregnancies were found to have preeclampsia after 20 weeks of gestation without a previous history of hypertension. On the other hand, the prevalence of preeclampsia that superimposed on chronic hypertension was found to be 5.4%. Serum levels of TC, LDL-C, ALT and uric acid were significantly higher and HDL-C was significantly lower in preeclamptic pregnancies than the non-preeclamptic pregnancies. Respondents who required to take antihypertensive medications (AOR 5.45, 95% CI [1.09, 27.31]) and who never took antenatal care (AOR 6.83, 95% CI [1.00, 46.48]) were more likely to be preeclamptic. In conclusion, the present study showed a comparatively high prevalence of preeclampsia among pregnant women in Bangladesh. Some programmatic interventions such as medication for hypertension, antenatal visits to doctors, delivery and postnatal care services should be considered to reduce and prevent the hypertensive pregnancy disorders in Bangladesh.
子痫前期是一种多器官系统妊娠疾病，是导致全球产妇发病率和死亡率升高的主要原因。在孟加拉国，每年都有大量的产科死亡病例，但具体原因并未得到充分调查。孟加拉国孕妇的子痫前期及其相关危险因素的数据有限。因此，我们旨在进行一项横断面研究，以评估孟加拉国孕妇队列中子痫前期的患病率，并确定可能的危险因素。在这项横断面研究中，共纳入了 111 名参与者，并要求他们在标准问卷中填写体重指数、社会人口统计学和其他相关生活方式信息。还从每位参与者收集血样，以标准方法分析血脂谱、肝酶、尿酸和肌酐的血清水平。采用逻辑回归分析来确定与子痫前期相关的因素。子痫前期的总体患病率为 14.4%。大约 10%的妊娠在没有高血压病史的情况下，在 20 周后被发现患有子痫前期。另一方面，发现子痫前期合并慢性高血压的患病率为 5.4%。与非子痫前期妊娠相比，子痫前期妊娠的血清 TC、LDL-C、ALT 和尿酸水平显著升高，而 HDL-C 水平显著降低。需要服用降压药物的受访者（AOR 5.45，95%CI [1.09，27.31]）和从未接受过产前护理的受访者（AOR 6.83，95%CI [1.00，46.48]）更有可能患子痫前期。总之，本研究显示孟加拉国孕妇子痫前期的患病率相对较高。应考虑采取一些计划干预措施，如高血压药物治疗、定期看医生、分娩和产后护理服务，以减少和预防孟加拉国的妊娠高血压疾病。
