Mulla Munaz, Hegde Shashikanth, Koshy Ajit, Mulla Mushir
Periodontology, Yenepoya University, Mangalore, IND.
Oral Pathology and Microbiology, M.A. Rangoonwala College of Dental Sciences and Research Centre, Pune, IND.
Cureus. 2021 Dec 29;13(12):e20808. doi: 10.7759/cureus.20808. eCollection 2021 Dec.
Background Varied treatment modalities have been described in the past for the management of peri-implant diseases but the evidence of the use of probiotics for the treatment of peri-implantitis is limited. The aim of this study was to determine the antagonistic growth effects of on the growth of peri-implantitis pathogens. Material and method Anin vitroassessment of probiotic on peri-implantitis pathogens was done using the serial tube dilution method. Minimum inhibitory concentration was calculated for five subgingival pathogens namely , , , , and Minimum inhibitory concentration (MIC) is defined as the lowermost concentration of any drug that prevents the noticeable growth of the test organism. In vitro assessment to determine the MIC is necessary for an in vivo application. The MIC value will also help to find the drug's accurate dosage. Results Peri-implantitis pathogens were cultured from individuals diagnosed with peri-implantitis. Except for all other pathogens were susceptible to the probiotic. had the lowest MIC (0.8mg/mL). Conclusion The MIC value for pathogens will help to determine the effective mode and form of probiotic that can be used for the treatment of peri-implantitis.
过去已经描述了多种用于治疗种植体周围疾病的治疗方式，但使用益生菌治疗种植体周炎的证据有限。本研究的目的是确定益生菌对种植体周炎病原体生长的拮抗作用。材料和方法：使用连续试管稀释法对益生菌对种植体周炎病原体进行体外评估。计算了五种龈下病原体即、、、和的最低抑菌浓度。最低抑菌浓度（MIC）定义为任何药物阻止受试生物体明显生长的最低浓度。体外评估以确定MIC对于体内应用是必要的。MIC值也将有助于找到药物的准确剂量。结果：从诊断为种植体周炎的个体中培养出种植体周炎病原体。除了之外，所有其他病原体对益生菌敏感。的MIC最低（0.8mg/mL）。结论：病原体的MIC值将有助于确定可用于治疗种植体周炎的益生菌的有效模式和形式。
