Schlagenhauf Ulrich, Jakob Lena, Eigenthaler Martin, Segerer Sabine, Jockel-Schneider Yvonne, Rehn Monika
Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany.
Department of Orthodontics, University Hospital Wuerzburg, Wuerzburg, Germany.
J Clin Periodontol. 2016 Nov;43(11):948-954. doi: 10.1111/jcpe.12606. Epub 2016 Aug 12.
This randomized controlled trial assessed the impact of Lactobacillus reuteri on pregnancy gingivitis in healthy women.
Forty-five healthy women (24 test/21 placebo) with pregnancy gingivitis in the third trimester of pregnancy were enrolled. At baseline Gingival Index (GI) and Plaque Index (PlI) were assessed at the Ramfjord teeth and venous blood taken for TNF-α analysis. Subsequently participants were randomly provided with lozenges to be consumed 2 × daily until birth (approx. 7 weeks) containing ≥10 CFU L. reuteri ATCC PTA 5289 and ≥10 CFU L. reuteri DSM 17938 (test) or being devoid of L. reuteri (placebo). Within 2 days after birth recording of GI, PlI and blood sampling were repeated.
At baseline, mean GI and mean PlI did not differ significantly between both groups. In the test group mean TNF-α serum level was significantly (p < 0.02) lower than in the placebo group. At reevaluation, mean GI and mean PlI of the test group were both significantly (p < 0.0001) lower than in the placebo group. Mean TNF-α serum level did no longer differ significantly between the groups.
The consumption of L. reuteri lozenges may be a useful adjunct in the control of pregnancy gingivitis.
本随机对照试验评估了罗伊氏乳杆菌对健康女性妊娠性龈炎的影响。
招募了45名孕晚期患有妊娠性龈炎的健康女性（24名试验组/21名安慰剂组）。在基线时，对Ramfjord牙位进行牙龈指数（GI）和菌斑指数（PlI）评估，并采集静脉血用于肿瘤坏死因子-α（TNF-α）分析。随后，随机为参与者提供含片，每天服用2次直至分娩（约7周），含片含有≥10 CFU罗伊氏乳杆菌ATCC PTA 5289和≥10 CFU罗伊氏乳杆菌DSM 17938（试验组）或不含罗伊氏乳杆菌（安慰剂组）。分娩后2天内，重复记录GI、PlI并进行血液采样。
在基线时，两组的平均GI和平均PlI无显著差异。试验组的平均TNF-α血清水平显著低于安慰剂组（p < 0.02）。在重新评估时，试验组的平均GI和平均PlI均显著低于安慰剂组（p < 0.0001）。两组间的平均TNF-α血清水平不再有显著差异。
食用罗伊氏乳杆菌含片可能是控制妊娠性龈炎的一种有用辅助方法。
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