Polymorphism of a Qa-1-associated antigen defined by cytotoxic T cells. I. Qed-1a and Qed-1d.

Tlad mice have a distinct Qed-1 allele, Qed-ld. Its product is detected by cytotoxic T cells raised in C57BL/6 (H-2b, Tlab) mice against cells from a new recombinant, B6-TL.123+ (H-2b, Tlad/b). Qed-1d is also found on cells from B10.M, A.CA and B10.STC90 mice. It cross-reacts weakly with Qed-1b (C57BL/6 x BALB/c)F1 anti-B10.A(5R) effectors discriminate Qed-1a and Qed-1d, while C3H/HeJ anti-B10.BR effectors cross-react extensively. CB6F1 anti-5R effector cells also discriminate between the Qed-1 antigens of B6-Tlaa (H-2b, Tlaa) and those of B10.BR and other H-2k, Tlaa strains.