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可被NZB T淋巴细胞无限制杀伤的母系传播靶抗原。

Maternally transmitted target antigen for unrestricted killing by NZB T lymphocytes.

作者信息

Fischer Lindahl K, Bocchieri M, Riblet R

出版信息

J Exp Med. 1980 Dec 1;152(6):1583-95. doi: 10.1084/jem.152.6.1583.

DOI:10.1084/jem.152.6.1583
PMID:6969774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186034/
Abstract

A new target antigen for unrestricted killing was defined by NZB T lymphocytes which were immunized and restimulated with H-2-identical BALB/c spleen cells. These effector cells killed nearly all target cells tested, irrespective of their H-2 type, but did not kill NZB target cells. The response was shown to have three major components: unrestricted killing specific for Qed-1b, H-2d-restricted killing specific for minor histocompatibility antigens, and unrestricted killing specific for a new antigen, Mta. Mta is present on normal and mitogen-stimulated T and B lymphocytes and on several tumor lines. It was found on cells from 26 mouse strains tested, including two substrains of NZB, representing 9 different H-2 types and 14 different non-H-2 backgrounds. Analysis of the NX8 recombinant inbred lines (derived from Mta-NZB/Icr and Mta+C58/J parents) suggested that Mta is maternally transmitted. This was confirmed by typing of reciprocal F1 hybrids and backcrosses between positive and negative strains: Mta+ females bear Mta+ offspring and Mta- females Mta- offspring, irrespective of the phenotype of the males.

摘要

一种用于无限制杀伤的新靶抗原由NZB T淋巴细胞定义，这些细胞用H-2相同的BALB/c脾细胞进行免疫和再刺激。这些效应细胞几乎能杀死所有测试的靶细胞，无论其H-2类型如何，但不能杀死NZB靶细胞。该反应显示有三个主要成分：对Qed-1b特异性的无限制杀伤、对次要组织相容性抗原特异性的H-2d限制杀伤以及对一种新抗原Mta特异性的无限制杀伤。Mta存在于正常和有丝分裂原刺激的T和B淋巴细胞以及几种肿瘤细胞系上。在测试的26种小鼠品系的细胞中发现了它，包括NZB的两个亚系，代表9种不同的H-2类型和14种不同的非H-2背景。对NX8重组近交系（源自Mta-NZB/Icr和Mta+C58/J亲本）的分析表明，Mta是母系遗传的。通过对正反交F1杂种和正反交品系之间回交的分型证实了这一点：Mta+雌性产生Mta+后代，Mta-雌性产生Mta-后代，与雄性的表型无关。

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本文引用的文献

1
Qed-1--a target for unrestricted killing by T cells.Qed-1——T细胞无限制杀伤的一个靶点。
Eur J Immunol. 1980 Apr;10(4):289-98. doi: 10.1002/eji.1830100413.
2
Antibody gene linkage studies in (NZB X C58) recombinant-inbred lines.（新西兰黑鼠×C58）重组近交系中的抗体基因连锁研究。
J Immunol. 1980 Feb;124(2):787-9.
3
Clonal induction of helper T cells: conversion of specific signals into nonspecific signals.辅助性T细胞的克隆诱导：将特异性信号转化为非特异性信号。
Int Arch Allergy Appl Immunol. 1980;61(2):227-37. doi: 10.1159/000232437.
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The immunology and pathology of NZB mice.NZB小鼠的免疫学与病理学
Adv Immunol. 1968;9:215-66. doi: 10.1016/s0065-2776(08)60444-7.
5
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
6
The mammary tumor virus (MTV).乳腺肿瘤病毒（MTV）。
Curr Top Microbiol Immunol. 1968;45:1-69. doi: 10.1007/978-3-642-50109-8_1.
7
Specific affinity fractionation of lymphocytes using glass or plastic bead columns.使用玻璃或塑料珠柱对淋巴细胞进行特异性亲和分级分离。
Scand J Immunol. 1976 Jun;Suppl 5:23-30. doi: 10.1111/j.1365-3083.1976.tb03853.x.
8
Genetic studies in NZB mice. I. Spontaneous autoantibody production.新西兰黑鼠的遗传学研究。I. 自发自身抗体产生
J Exp Med. 1978 May 1;147(5):1487-1502. doi: 10.1084/jem.147.5.1487.
9
Primary in vitro cell-mediated lympholysis reaction of NZB mice against unmodified targets syngeneic at the major histocompatibility complex.新西兰黑小鼠针对主要组织相容性复合体同基因未修饰靶标的原发性体外细胞介导的淋巴细胞溶解反应。
J Exp Med. 1978 May 1;147(5):1435-48. doi: 10.1084/jem.147.5.1435.
10
Primary in vitro cytotoxic response of NZB spleen cells to Qa-1b-associated antigenic determinants.NZB脾细胞对Qa-1b相关抗原决定簇的原发性体外细胞毒性反应。
J Exp Med. 1979 Dec 1;150(6):1555-60. doi: 10.1084/jem.150.6.1555.

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