可被NZB T淋巴细胞无限制杀伤的母系传播靶抗原。

Maternally transmitted target antigen for unrestricted killing by NZB T lymphocytes.

作者信息

Fischer Lindahl K, Bocchieri M, Riblet R

出版信息

J Exp Med. 1980 Dec 1;152(6):1583-95. doi: 10.1084/jem.152.6.1583.

DOI:10.1084/jem.152.6.1583

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186034/

Abstract

A new target antigen for unrestricted killing was defined by NZB T lymphocytes which were immunized and restimulated with H-2-identical BALB/c spleen cells. These effector cells killed nearly all target cells tested, irrespective of their H-2 type, but did not kill NZB target cells. The response was shown to have three major components: unrestricted killing specific for Qed-1b, H-2d-restricted killing specific for minor histocompatibility antigens, and unrestricted killing specific for a new antigen, Mta. Mta is present on normal and mitogen-stimulated T and B lymphocytes and on several tumor lines. It was found on cells from 26 mouse strains tested, including two substrains of NZB, representing 9 different H-2 types and 14 different non-H-2 backgrounds. Analysis of the NX8 recombinant inbred lines (derived from Mta-NZB/Icr and Mta+C58/J parents) suggested that Mta is maternally transmitted. This was confirmed by typing of reciprocal F1 hybrids and backcrosses between positive and negative strains: Mta+ females bear Mta+ offspring and Mta- females Mta- offspring, irrespective of the phenotype of the males.

摘要

一种用于无限制杀伤的新靶抗原由NZB T淋巴细胞定义，这些细胞用H-2相同的BALB/c脾细胞进行免疫和再刺激。这些效应细胞几乎能杀死所有测试的靶细胞，无论其H-2类型如何，但不能杀死NZB靶细胞。该反应显示有三个主要成分：对Qed-1b特异性的无限制杀伤、对次要组织相容性抗原特异性的H-2d限制杀伤以及对一种新抗原Mta特异性的无限制杀伤。Mta存在于正常和有丝分裂原刺激的T和B淋巴细胞以及几种肿瘤细胞系上。在测试的26种小鼠品系的细胞中发现了它，包括NZB的两个亚系，代表9种不同的H-2类型和14种不同的非H-2背景。对NX8重组近交系（源自Mta-NZB/Icr和Mta+C58/J亲本）的分析表明，Mta是母系遗传的。通过对正反交F1杂种和正反交品系之间回交的分型证实了这一点：Mta+雌性产生Mta+后代，Mta-雌性产生Mta-后代，与雄性的表型无关。

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本文引用的文献

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Qed-1--a target for unrestricted killing by T cells.

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