Mta是小鼠的一种母系遗传细胞表面抗原，通过卵子传递。
Mta, a maternally inherited cell surface antigen of the mouse, is transmitted in the egg.
作者信息
Lindahl K F, Bürki K
出版信息
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5362-6. doi: 10.1073/pnas.79.17.5362.
Abstract
Mta is a maternally transmitted cell surface antigen found in most mouse strains. It serves as a target for unrestricted T killer cells. All 49 embryos transferred between positive and negative mothers, even as early as 10-15 hr after fertilization, developed into mice with the Mta type of their original mothers. Therefore the genetic element that determines expression of Mta must be transmitted by the egg. Mta+ and Mta- lymphocytes, coexisting for months in lethally irradiated F1 mice reconstituted with a mixture of parental bone marrow cells, retained their Mta type. Thus Mta does not spread by infection.
摘要
Mta是一种在大多数小鼠品系中发现的母系传播的细胞表面抗原。它是不受限制的T杀伤细胞的靶标。在阳性和阴性母亲之间转移的所有49个胚胎，即使在受精后10 - 15小时这么早的时候，都发育成具有其原始母亲Mta类型的小鼠。因此，决定Mta表达的遗传元件必定由卵子传递。Mta +和Mta -淋巴细胞，在用亲本骨髓细胞混合物重建的致死性照射的F1小鼠中共存数月，保持它们的Mta类型。因此，Mta不会通过感染传播。
相似文献
1
Mta, a maternally inherited cell surface antigen of the mouse, is transmitted in the egg.Mta是小鼠的一种母系遗传细胞表面抗原，通过卵子传递。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5362-6. doi: 10.1073/pnas.79.17.5362.
2
Cytoplasmic inheritance of a cell surface antigen in the mouse.小鼠细胞表面抗原的细胞质遗传
Genetics. 1983 Mar;103(3):483-94. doi: 10.1093/genetics/103.3.483.
3
Maternally transmitted target antigen for unrestricted killing by NZB T lymphocytes.可被NZB T淋巴细胞无限制杀伤的母系传播靶抗原。
J Exp Med. 1980 Dec 1;152(6):1583-95. doi: 10.1084/jem.152.6.1583.
4
5
A new H-2-linked class I gene whose expression depends on a maternally inherited factor.一个新的与H-2连锁的I类基因，其表达依赖于母系遗传因子。
Nature. 1983;306(5941):383-5. doi: 10.1038/306383a0.
6
Mta, the maternally transmitted antigen, is determined jointly by the chromosomal Hmt and the extrachromosomal Mtf genes.母系传播抗原Mta由染色体Hmt基因和染色体外Mtf基因共同决定。
J Exp Med. 1986 Feb 1;163(2):334-46. doi: 10.1084/jem.163.2.334.
7
Maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial DNA.母系遗传抗原由含有两种线粒体DNA的小鼠细胞共显性表达。
J Exp Med. 1987 Feb 1;165(2):560-5. doi: 10.1084/jem.165.2.560.
8
Mitochondria control expression of a murine cell surface antigen.线粒体控制一种小鼠细胞表面抗原的表达。
Nature. 1983;306(5943):599-601. doi: 10.1038/306599a0.
9
Cosegregation of monoclonal antibody reactivity and cell behaviour in the mouse preimplantation embryo.小鼠植入前胚胎中单克隆抗体反应性与细胞行为的共分离
J Embryol Exp Morphol. 1982 Aug;70:261-78.
10
Mitochondrial modulation of maternally transmitted antigen: analysis of cell hybrids.母系遗传抗原的线粒体调控：细胞杂交体分析
Proc Natl Acad Sci U S A. 1985 May;82(10):3286-90. doi: 10.1073/pnas.82.10.3286.
引用本文的文献
1
Survival of skin graft between transgenic cloned dogs and non-transgenic cloned dogs.转基因克隆犬与非转基因克隆犬之间皮肤移植的存活情况。
PLoS One. 2014 Nov 5;9(11):e108330. doi: 10.1371/journal.pone.0108330. eCollection 2014.
2
Unusual type of mitochondrial DNA in mice lacking a maternally transmitted antigen.缺乏母系传播抗原的小鼠中异常类型的线粒体DNA。
Nucleic Acids Res. 1983 May 11;11(9):2917-26. doi: 10.1093/nar/11.9.2917.
3
Differences in maternal lineages of New Zealand Black mice defined by restriction endonuclease analysis of mitochondrial DNA and by expression of maternally transmitted antigen.通过线粒体DNA的限制性内切酶分析和母系传播抗原的表达确定的新西兰黑鼠母系谱系差异。
J Exp Med. 1983 Jun 1;157(6):2154-9. doi: 10.1084/jem.157.6.2154.
4
Mta, the maternally transmitted antigen, is determined jointly by the chromosomal Hmt and the extrachromosomal Mtf genes.母系传播抗原Mta由染色体Hmt基因和染色体外Mtf基因共同决定。
J Exp Med. 1986 Feb 1;163(2):334-46. doi: 10.1084/jem.163.2.334.
5
Cytoplasmic mediation of malignancy.恶性肿瘤的细胞质介导
In Vitro Cell Dev Biol. 1988 May;24(5):487-90. doi: 10.1007/BF02628504.
6
Mitochondrial modulation of maternally transmitted antigen: analysis of cell hybrids.母系遗传抗原的线粒体调控：细胞杂交体分析
Proc Natl Acad Sci U S A. 1985 May;82(10):3286-90. doi: 10.1073/pnas.82.10.3286.
7
Genetic and molecular mapping of the Hmt region of mouse.小鼠Hmt区域的遗传与分子图谱
EMBO J. 1989 Dec 1;8(12):3749-57. doi: 10.1002/j.1460-2075.1989.tb08551.x.
8
Unglycosylated Mtaa expresses an Mtab-like determinant.
Immunogenetics. 1987;25(4):234-40. doi: 10.1007/BF00404693.
本文引用的文献
1
Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.分泌针对小鼠H-2和Ia抗原的单克隆抗体的杂交瘤细胞系。
J Immunol. 1980 Feb;124(2):533-40.
2
Polymorphism of a Qa-1-associated antigen defined by cytotoxic T cells. I. Qed-1a and Qed-1d.
Eur J Immunol. 1982 Feb;12(2):159-66. doi: 10.1002/eji.1830120211.
3
Maternally transmitted target antigen for unrestricted killing by NZB T lymphocytes.可被NZB T淋巴细胞无限制杀伤的母系传播靶抗原。
J Exp Med. 1980 Dec 1;152(6):1583-95. doi: 10.1084/jem.152.6.1583.
4
Qed-1--a target for unrestricted killing by T cells.Qed-1——T细胞无限制杀伤的一个靶点。
Eur J Immunol. 1980 Apr;10(4):289-98. doi: 10.1002/eji.1830100413.
5
Monoclonal rat anti-major histocompatibility complex antibodies display specificity for rat, mouse, and human target cells.单克隆大鼠抗主要组织相容性复合体抗体对大鼠、小鼠和人类靶细胞具有特异性。
J Exp Med. 1980 May 1;151(5):1139-50. doi: 10.1084/jem.151.5.1139.
6
Fertilization in vitro and development of mouse ova.小鼠卵子的体外受精与发育
Biol Reprod. 1973 May;8(4):420-6. doi: 10.1093/biolreprod/8.4.420.
7
Fine specificity analysis with monoclonal antibodies of antigens controlled by the major histocompatibility complex and by the Qa/TL region in mice.利用单克隆抗体对小鼠主要组织相容性复合体和Qa/TL区域所控制抗原进行的精细特异性分析。
Immunol Rev. 1979;47:175-206. doi: 10.1111/j.1600-065x.1979.tb00293.x.
8
Production and characterization of cytotoxic Thy-1 antibody-secreting hybrid cell lines. Detection of T cell subsets.细胞毒性Thy-1抗体分泌杂交细胞系的产生与特性分析。T细胞亚群的检测。
Eur J Immunol. 1979 Nov;9(11):875-86. doi: 10.1002/eji.1830091109.
Zotero 插件