Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Curr Osteoporos Rep. 2022 Feb;20(1):53-64. doi: 10.1007/s11914-022-00721-2. Epub 2022 Feb 3.
Osteoblasts are responsible for bone matrix production during bone development and homeostasis. Much is known about the transcriptional regulation and signaling pathways governing osteoblast differentiation. However, less is known about how osteoblasts obtain or utilize nutrients to fulfill the energetic demands associated with osteoblast differentiation and bone matrix synthesis. The goal of this review is to highlight and discuss what is known about the role and regulation of bioenergetic metabolism in osteoblasts with a focus on more recent studies.
Bioenergetic metabolism has emerged as an important regulatory node in osteoblasts. Recent studies have begun to identify the major nutrients and bioenergetic pathways favored by osteoblasts as well as their regulation during differentiation. Here, we highlight how osteoblasts obtain and metabolize glucose, amino acids, and fatty acids to provide energy and other metabolic intermediates. In addition, we highlight the signals that regulate nutrient uptake and metabolism and focus on how energetic metabolism promotes osteoblast differentiation. Bioenergetic metabolism provides energy and other metabolites that are critical for osteoblast differentiation and activity. This knowledge contributes to a more comprehensive understanding of osteoblast biology and may inform novel strategies to modulate osteoblast differentiation and bone anabolism in patients with bone disorders.
成骨细胞负责骨发育和稳态过程中的骨基质生成。人们对调控成骨细胞分化的转录调控和信号通路了解较多。但对于成骨细胞如何获取或利用营养物质来满足与成骨细胞分化和骨基质合成相关的能量需求，人们知之甚少。本文的目的是强调并讨论生物能量代谢在成骨细胞中的作用和调控，重点介绍最近的研究进展。
生物能量代谢已成为成骨细胞中的一个重要调控节点。最近的研究开始确定成骨细胞偏好的主要营养物质和生物能量途径，以及它们在分化过程中的调控。在这里，我们重点介绍成骨细胞如何获取和代谢葡萄糖、氨基酸和脂肪酸，以提供能量和其他代谢中间产物。此外，我们还强调了调节营养物质摄取和代谢的信号，并重点关注能量代谢如何促进成骨细胞分化。生物能量代谢为成骨细胞分化和活性提供能量和其他代谢物，这对于成骨细胞生物学的理解具有重要意义，并可能为调控骨代谢疾病中成骨细胞分化和骨合成提供新策略。
