Department of Public Health Sciences, Clemson University, 513 Edwards Hall, Clemson, SC, 29634, U.S.A.
Department of Biobehavioral Health and Nursing Science, College of Nursing, University of South Carolina, 1601 Greene St, Columbia, SC, 29208, U.S.A.
J Community Health. 2024 Feb;49(1):100-107. doi: 10.1007/s10900-023-01251-3. Epub 2023 Aug 2.
African American adults have the highest mortality rate for most cancers in the United States, and meaningful, community-driven research is needed to inform optimal strategies for addressing these disparities. Unfortunately, research mistrust, often driven by historical inequities, is well-documented among African Americans.This study explored trust, attitudes, and preferences regarding participation in cancer research activities among primarily African American and other medically underserved communities in South Carolina from August 2020 to December 2021. Trust was measured using the Trust in Medical Researchers Scale (TMRS).The mean TMRS score for all study participants (N = 179) was 26.54 (SD 7.57) out of 48 (maximum possible score). Significant differences in mean values of the TMRS scores were only observed for gender (p = 0.0056) and race (p < 0.0001), with White participants and males reporting higher levels of trust in medical researchers. Overall, 52.5% of participants were somewhat likely or likely to volunteer to participate in a cancer research opportunity, with White participants (73.81%) being more likely to participate in cancer research compared to African American participants (45.74%) (p = 0.0054). Furthermore, participants were most willing to provide saliva (80.85%) and urine samples (80.85%), new blood samples (60.64%), stool samples (54.26%), medical records or laboratory results (52.13%) and least willing to allow left-over blood, tissue, or other fluids from medical procedures to be used for research (50%).These results provide evidence of the need for concerted programmatic efforts to build trust in cancer researchers, particularly among females and African American adults.
美国的非裔成年人在大多数癌症中的死亡率最高，需要进行有意义的、以社区为导向的研究，为解决这些差异提供最佳策略。不幸的是，非裔美国人中存在着严重的研究不信任现象，这主要是由于历史上的不平等造成的。本研究于 2020 年 8 月至 2021 年 12 月在南卡罗来纳州的非裔和其他医疗服务不足的社区中，探索了对参与癌症研究活动的信任、态度和偏好。使用医疗研究人员信任量表（TMRS）来衡量信任。所有研究参与者（N=179）的 TMRS 平均得分为 26.54（SD=7.57），满分 48 分。TMRS 评分的平均值仅在性别（p=0.0056）和种族（p<0.0001）上存在显著差异，白人参与者和男性报告对医疗研究人员的信任度更高。总体而言，52.5%的参与者表示有些可能或可能会自愿参加癌症研究机会，与非裔参与者（45.74%）相比，白人参与者（73.81%）更有可能参加癌症研究（p=0.0054）。此外，参与者最愿意提供唾液（80.85%）和尿液样本（80.85%）、新的血液样本（60.64%）、粪便样本（54.26%）、医疗记录或实验室结果（52.13%），而最不愿意允许从医疗程序中剩余的血液、组织或其他液体用于研究（50%）。这些结果表明，需要有协调一致的方案努力来建立对癌症研究人员的信任，尤其是在女性和非裔成年人中。
