Stressed and disoriented: stromal autophagy regulates HSCs.
作者信息
Hurwitz Stephanie N, Kurre Peter
机构信息
University of Pennsylvania.
Children's Hospital of Philadelphia.
出版信息
Blood. 2022 Feb 3;139(5):640-642. doi: 10.1182/blood.2021014337.
Abstract
摘要
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本文引用的文献
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Autophagy in mesenchymal progenitors protects mice against bone marrow failure after severe intermittent stress.间充质祖细胞中的自噬可保护小鼠免受严重间歇性应激后骨髓衰竭。
Blood. 2022 Feb 3;139(5):690-703. doi: 10.1182/blood.2021011775.
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Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma.骨髓再生需要供体表达 Cx43 的造血祖细胞向基质转移线粒体。
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Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence.自噬在间充质干细胞衰老调控中的双重作用
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Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular.溶酶体胞吐作用、外泌体释放和分泌自噬：自噬和内溶酶体系统向细胞外延伸。
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An early-senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro-inflammatory program.衰老间充质基质细胞的早期衰老状态通过激活促炎程序导致造血干/祖细胞集落形成能力受损。
Aging Cell. 2019 Jun;18(3):e12933. doi: 10.1111/acel.12933. Epub 2019 Mar 3.
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Autophagy maintains the metabolism and function of young and old stem cells.自噬维持年轻和衰老干细胞的新陈代谢及功能。
Nature. 2017 Mar 9;543(7644):205-210. doi: 10.1038/nature21388. Epub 2017 Mar 1.
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Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells.小生境WNT5A在造血干细胞再生过程中调节肌动蛋白细胞骨架。
J Exp Med. 2017 Jan;214(1):165-181. doi: 10.1084/jem.20151414. Epub 2016 Dec 20.
8
Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells.间隙连接蛋白 43 通过将活性氧转移至骨髓基质细胞来防止造血干细胞衰老。
Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9071-6. doi: 10.1073/pnas.1120358109. Epub 2012 May 18.
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Concise review: polarity in stem cells, disease, and aging.简明综述：干细胞、疾病和衰老中的极性。
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10
Mitochondrial transfer between cells can rescue aerobic respiration.细胞间的线粒体转移可挽救有氧呼吸。
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1283-8. doi: 10.1073/pnas.0510511103. Epub 2006 Jan 23.
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