Yang Shijie, Xu Xiequn
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Endocrine. 2022 May;76(2):377-384. doi: 10.1007/s12020-022-02996-y. Epub 2022 Feb 3.
There is a lack of research on short-term mental health and health-related quality of life (HRQoL) in thyroid cancer patients. This study aimed to assess the short-term anxiety level and HRQoL of patients during the early postoperative period while awaiting pathology results, and to explore the important factors associated with state anxiety.
In this single-center cross-sectional study, 349 patients with papillary thyroid cancer were included. Anxiety and HRQoL were measured using the State-Trait Anxiety Inventory (STAI) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30), respectively.
In general, papillary thyroid cancer patients reported good quality of life with a mean global quality of life score of 75.69 ± 20.66 (on a scale of 0-100, where 100 means the best). There was no significant difference in HRQoL between the two groups, except regarding social functioning (p = 0.027). The anxiety levels of the two groups were similar; however, the state anxiety score (42.17 ± 12.52) was significantly higher than the trait anxiety score (40.69 ± 11.18) among patients in the non-FNA group (p = 0.023). Dyspnea, insomnia, QL, and trait anxiety were independent factors that affected state anxiety.
Patients with papillary thyroid cancer had good postoperative HRQoL and a significantly higher than usual level of state anxiety while awaiting pathology results. Symptoms of dyspnea and insomnia, global quality of life, and trait anxiety are important factors associated with state anxiety. Preoperative FNA results may moderate the change in anxiety level. These findings may help clinicians provide psychological support.
甲状腺癌患者短期心理健康及健康相关生活质量（HRQoL）方面的研究较少。本研究旨在评估甲状腺癌患者术后早期等待病理结果期间的短期焦虑水平和HRQoL，并探讨与状态焦虑相关的重要因素。
在这项单中心横断面研究中，纳入了349例乳头状甲状腺癌患者。分别使用状态-特质焦虑量表（STAI）和欧洲癌症研究与治疗组织生活质量问卷（EORTC-QLQ-C30）测量焦虑和HRQoL。
总体而言，乳头状甲状腺癌患者报告生活质量良好，平均总体生活质量评分为75.69±20.66（范围为0至100，其中100表示最佳）。除社会功能外，两组之间的HRQoL无显著差异（p = 0.027）。两组的焦虑水平相似；然而，非细针穿刺抽吸活检（FNA）组患者的状态焦虑评分（42.17±12.52）显著高于特质焦虑评分（40.69±11.18）（p = 0.023）。呼吸困难、失眠、生活质量和特质焦虑是影响状态焦虑的独立因素。
乳头状甲状腺癌患者术后HRQoL良好，在等待病理结果期间状态焦虑水平显著高于平常。呼吸困难和失眠症状、总体生活质量以及特质焦虑是与状态焦虑相关的重要因素。术前FNA结果可能会缓和焦虑水平的变化。这些发现可能有助于临床医生提供心理支持。
