妊娠期间重度特应性皮炎使用度普利尤单抗：一例病例报告。
The use of dupilumab in severe atopic dermatitis during pregnancy: a case report.
作者信息
Akhtar Nabeel H, Khosravi-Hafshejani Touraj, Akhtar Daud, Dhadwal Gurbir, Kanani Amin
机构信息
School of Medicine, University College Dublin, Dublin, Ireland.
Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.
出版信息
Allergy Asthma Clin Immunol. 2022 Feb 3;18(1):9. doi: 10.1186/s13223-022-00650-w.
Abstract
BACKGROUND
Atopic dermatitis is a common chronic skin disease that can occur in pregnancy. Current treatments include topical and systemic glucocorticoids and cyclosporine. Presently, the only biologic approved for atopic dermatitis is dupilumab with limited data available regarding its safety profile in pregnancy.
CASE PRESENTATION
We report a case of severe atopic dermatitis treated safely with dupilumab with no adverse maternal or fetal outcomes and resolution of atopic dermatitis postpartum in the absence of maintenance dupilumab therapy.
CONCLUSION
Here we demonstrate the safe use of dupilumab in pregnancy. Further research is needed to elucidate the role of dupilumab in the management of atopic dermatitis during pregnancy.
摘要
背景
特应性皮炎是一种常见的慢性皮肤病，可发生于妊娠期。目前的治疗方法包括局部和全身使用糖皮质激素以及环孢素。目前，唯一被批准用于特应性皮炎的生物制剂是度普利尤单抗，但关于其在妊娠期的安全性资料有限。
病例报告
我们报告了一例严重特应性皮炎患者，在未进行度普利尤单抗维持治疗的情况下，使用度普利尤单抗安全治疗，未出现不良母体或胎儿结局，产后特应性皮炎得到缓解。
结论
在此我们证明了度普利尤单抗在妊娠期的安全使用。需要进一步研究以阐明度普利尤单抗在妊娠期特应性皮炎管理中的作用。
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