Awake pronation with helmet continuous positive airway pressure for COVID-19 acute respiratory distress syndrome patients outside the ICU: A case series.

OBJECTIVE

Continuous positive airway pressure (CPAP) is an important therapeutic tool in COVID-19 acute respiratory distress syndrome (ARDS) since it improves oxygenation, reduces respiratory rate and can prevent intubation and intensive care unit (ICU) admission. CPAP during pronation has seldom been described and never during sedation.

DESIGN

Case series.

SETTING

High dependency unit of San Carlo University Hospital (Potenza, Italy).

PATIENTS

Eleven consecutive patients with COVID-19 ARDS.

INTERVENTION

Helmet CPAP in prone position after failing a CPAP trial in the supine position.

MAIN VARIABLE OF INTEREST

Data collection at baseline and then after 24, 48 and 72h of pronation. We measured PaO/FIO, pH, lactate, PaCO, SpO, respiratory rate and the status of the patients at 28-day follow up.

RESULTS

Patients were treated with helmet CPAP for a mean±SD of 7±2.7 days. Prone positioning was feasible in all patients, but in 7 of them dexmedetomidine improved comfort. PaO/FIO improved from 107.5±20.8 before starting pronation to 244.4±106.2 after 72h (p<.001). We also observed a significantly increase in Sp0 from 90.6±2.3 to 96±3.1 (p<.001) and a decrease in respiratory rate from 27.6±4.3 to 20.1±4.7 (p=.004). No difference was observed in PaCO or pH. At 28 days two patients died after ICU admission, one was discharged in the main ward after ICU admission and eight were discharged home after being successfully managed outside the ICU.

CONCLUSIONS

Helmet CPAP during pronation was feasible and safe in COVID-19 ARDS managed outside the ICU and sedation with dexmedetomidine safely improved comfort. We recorded an increase in PaO/FIO, SpO and a reduction in respiratory rate.