Bara J, Zabaleta E H, Mollicone R, Nap M, Burtin P
Am J Clin Pathol. 1986 Feb;85(2):152-9. doi: 10.1093/ajcp/85.2.152.
Through the immunoperoxidase method using antibody 19-9, we demonstrated the presence of gastrointestinal cancer-associated antigen (GICA) in normal gastrointestinal and endocervical mucosae and in benign mucinous ovarian cysts of pure endocervical type in Le(a+b-) and Le(a-b+) patients exclusively. However, GICA was more quantitatively expressed in Le(a+b-) than in Le(a-b+) patients. GICA was always encountered in the ducts of esophageal glands, Wirsung's ducts, goblet cells of villosities near the ileo-colonic junction, and the mucus columnar cells of the endocervical mucosae or ovarian mucinous tumor epithelium. In other areas of the gastrointestinal tract, GICA was sometimes found in the mucus cells of esophageal glands, near the neck cells of gastric mucosae, in goblet cells of the upper part of the small intestinal villosities, and in colonic Lieberkühn glands, especially in the cell maturation compartment. GICA therefore appears to be a normal component of gastrointestinal and endocervical mucosae.
通过使用19-9抗体的免疫过氧化物酶方法，我们仅在Le(a+b-)和Le(a-b+)患者的正常胃肠道和宫颈内膜黏膜以及纯宫颈内膜型的良性黏液性卵巢囊肿中证实了胃肠癌相关抗原（GICA）的存在。然而，GICA在Le(a+b-)患者中的表达量比在Le(a-b+)患者中更高。在食管腺导管、胰管、回结肠交界处附近绒毛的杯状细胞以及宫颈内膜黏膜或卵巢黏液性肿瘤上皮的黏液柱状细胞中总是能检测到GICA。在胃肠道的其他区域，有时在食管腺的黏液细胞、胃黏膜颈部细胞附近、小肠绒毛上部的杯状细胞以及结肠利伯kühn腺中发现GICA，特别是在细胞成熟区。因此，GICA似乎是胃肠道和宫颈内膜黏膜的正常组成部分。
