Bara J, Loisillier F, Burtin P
Br J Cancer. 1980 Feb;41(2):209-21. doi: 10.1038/bjc.1980.32.
Using immunofluorescence methods, 3 antisera respectively stain 3 groups of mucous cells of the human gastrointestinal tract, showing specific antigens for each group of cells. The antigens of the first group, the M1 antigens, were principally associated with columnar cells of the gastric epithelium, the M2 antigens with mucous cells of gastric and Brünner's glands, and the M3 antigen with the goblet cells of the intestinal mucosa. The gastric M antigens normally detectable in stomach and duodenum (but not in colon) were expressed in certain colonic tumours (benign or malignant) and in adjacent mucosa. They are always present with the intestinal M3 antigen. In 100 colonic adenocarcinomas, the intestinal M3 antigen was found in 53 cases, gastric M1 antigens in 29 cases, and gastric M2 antigens in 10 cases, always with the two other M antigens. A good correlation could be established between the association of M antigens and the histological type of tumour.
采用免疫荧光法，3种抗血清分别对人胃肠道的3组黏液细胞进行染色，显示出每组细胞的特异性抗原。第一组抗原即M1抗原，主要与胃上皮的柱状细胞相关；M2抗原与胃及布伦纳腺的黏液细胞相关；M3抗原与肠黏膜的杯状细胞相关。正常情况下在胃和十二指肠（而非结肠）中可检测到的胃M抗原，在某些结肠肿瘤（良性或恶性）及相邻黏膜中表达。它们总是与肠M3抗原同时存在。在100例结肠腺癌中，53例发现有肠M3抗原，29例有胃M1抗原，10例有胃M2抗原，且总是与另外两种M抗原同时存在。M抗原的组合与肿瘤的组织学类型之间可建立良好的相关性。
