Zhao Xuan-Yu, Kong Wei-Min, Jiao Si-Meng, Song Dan, Chen Jiao, Shang Ruo-Tian
Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100006, China.
Transl Cancer Res. 2020 Mar;9(3):1978-1984. doi: 10.21037/tcr.2020.01.59.
To investigate the incidence of single and multiple human papillomavirus (HR-HPV) infection in CIN3 patients before operation.
The complete clinical data of patients with CIN3 by biopsy were collected. HPV23 typing in the first 3 months of the treatment was detected. The infection rate of HPV was analyzed.
One thousand and fifty-one HPV subtypes were detected in 679 patients with HPV (+) CIN3 with primary conization, of which the top ten were HPV16, 33, 31, 58, 6, 52, 18, 43, 51, 11, 68, respectively. Among them, single subtype HPV infection accounted for 64.36%, while multiple HPV infection accounted for 35.64%. For multiplex HPV infection, there were 2, 3, 4 species, and 148 (21.80%), 69 (10.16%), 16 (2.36%), 9 (1.33%) cases of multiple HPV infection of 5 and above HPV subtypes respectively. The incidence of multiple HPV infection in CIN3 patients in 2015 was higher than that in 2012 (39.01% 30.08%, P=0.019), and the proportion of multiple infections in HPV was higher than that in the 2014 group.
The top 10 HPV subtypes of the CIN3 patients were included in HPV nine valence vaccines except HPV43 and 51.
探讨CIN3患者术前单一和多重人乳头瘤病毒（HR-HPV）感染的发生率。
收集经活检确诊为CIN3患者的完整临床资料。检测治疗前3个月内的HPV 23型。分析HPV感染率。
679例HPV（+）CIN3初次锥切患者共检测出1051种HPV亚型，其中前10位分别为HPV16、33、31、58、6、52、18、43、51、11、68。其中，单一亚型HPV感染占64.36%，多重HPV感染占35.64%。对于多重HPV感染，有2、3、4种，以及分别有148例（21.80%）、69例（10.16%）、16例（2.36%）、9例（1.33%）为5种及以上HPV亚型的多重HPV感染。2015年CIN3患者多重HPV感染发生率高于2012年（39.01%对30.08%，P = 0.019），且HPV多重感染比例高于2014年组。
CIN3患者的前10种HPV亚型中，除HPV43和51外，均包含在HPV九价疫苗中。
