Muss Hyman B, Smitherman Andrew, Wood William A, Nyrop Kirsten, Tuchman Sascha, Randhawa Paramjeet K, Entwistle Amy R, Mitin Natalia, Shachar Shlomit S
Department of Medicine, University of North Carolina School of Medicine and the Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.
Department of Pediatrics, University of North Carolina School of Medicine and the Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.
Transl Cancer Res. 2020 Sep;9(9):5732-5742. doi: 10.21037/tcr.2020.03.39.
There is great variability in life-expectancy, physical, cognitive, and functional domains in cancer patients of similar chronologic age. Nowhere is this more apparent than among middle-aged and older patients. However, even in younger patients of similar age, extensive exposure to environmental stressors can cause great variability in health status. A biomarker that would reflect biologic age and any and all health deficits in a cancer patient at a distinct point in time might help predict long term outcomes related to treatment, especially toxicity and overall survival. p16 (hereafter referred to as p16) expression represents an ideal biomarker that reflects both cellular senescence and biologic aging. In murine models, p16 expression reflects biologic aging in almost all organs. Preliminary findings in patients with cancer support p16 measurement as a marker of physiologic aging and predictor of toxicity in patients treated with chemotherapy. This review describes the role of p16 in cell senescence, the methodology of p16 measurement in humans, preliminary studies of p16 in humans, and the potential clinical utility of p16 in guiding treatment for cancer patients.
在年龄相仿的癌症患者中，预期寿命、身体、认知和功能领域存在很大差异。这在中年及老年患者中表现得最为明显。然而，即使在年龄相仿的年轻患者中，长期暴露于环境应激源也会导致健康状况出现很大差异。一种能够在特定时间点反映癌症患者生物学年龄以及所有健康缺陷的生物标志物，可能有助于预测与治疗相关的长期结果，尤其是毒性和总生存期。p16（以下简称p16）表达是一种理想的生物标志物，它既反映细胞衰老又反映生物学衰老。在小鼠模型中，p16表达反映了几乎所有器官的生物学衰老。癌症患者的初步研究结果支持将p16检测作为生理衰老的标志物以及化疗患者毒性的预测指标。本综述描述了p16在细胞衰老中的作用、人类p16检测方法、p16在人类中的初步研究以及p16在指导癌症患者治疗方面的潜在临床应用。
