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Association of p16(INK4a), a biomarker of cellular senescence, with receipt of therapy and frailty status among adults with plasma cell disorders.细胞衰老生物标志物p16（INK4a）与浆细胞疾病成人患者的治疗接受情况及虚弱状态的关联。
J Geriatr Oncol. 2025 May;16(4):102174. doi: 10.1016/j.jgo.2024.102174. Epub 2024 Dec 20.
2
Accelerated aging among childhood, adolescent, and young adult cancer survivors is evidenced by increased expression of p16 and frailty.儿童、青少年和青年癌症幸存者存在加速衰老现象，其表现为 p16 表达增加和虚弱。
Cancer. 2020 Nov 15;126(22):4975-4983. doi: 10.1002/cncr.33112. Epub 2020 Aug 24.
3
SATB2, coordinated with CUX1, regulates IL-1β-induced senescence-like phenotype in endothelial cells by fine-tuning the atherosclerosis-associated p16 expression.SATB2 通过精细调控动脉粥样硬化相关的 p16 表达，与 CUX1 协同调节内皮细胞中 IL-1β 诱导的衰老样表型。
Aging Cell. 2023 Feb;22(2):e13765. doi: 10.1111/acel.13765. Epub 2023 Jan 12.
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Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.肿瘤抑制因子和衰老生物标志物 p16(INK4a) 在没有相关炎症分泌表型的情况下诱导细胞衰老。
J Biol Chem. 2011 Oct 21;286(42):36396-403. doi: 10.1074/jbc.M111.257071. Epub 2011 Aug 31.
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Role of senescence marker p16 INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults.衰老标志物p16 INK4a在外周血T淋巴细胞中的检测在预测老年人冠状动脉搭桥术后住院时间方面的作用。
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Cellular senescence marker p16 and NFKB1 gene polymorphisms in lower gastro-intestinal acute graft versus host disease.下消化道急性移植物抗宿主病中的细胞衰老标志物p16和NFKB1基因多态性
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A brief report on biomarkers of cellular senescence associated with liver frailty and length of stay in liver transplantation.关于与肝脏脆弱性及肝移植住院时间相关的细胞衰老生物标志物的简要报告。
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p16INK4a-induced senescence is disabled by melanoma-associated mutations.p16INK4a诱导的衰老被黑色素瘤相关突变所抑制。
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p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.p16（Ink4a）诱导的胰腺β细胞衰老增强胰岛素分泌。
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本文引用的文献

1
Determining the relationship of p16 and additional molecular markers of aging with clinical frailty in hematologic malignancy.探讨血液恶性肿瘤中 p16 与其他衰老分子标志物与临床虚弱的关系。
J Cancer Surviv. 2024 Aug;18(4):1168-1178. doi: 10.1007/s11764-024-01591-6. Epub 2024 Apr 28.
2
p16 a biomarker of aging and tolerance for cancer therapy.p16是衰老和癌症治疗耐受性的生物标志物。
Transl Cancer Res. 2020 Sep;9(9):5732-5742. doi: 10.21037/tcr.2020.03.39.
3
Geriatric-assessment-identified functional deficits among adults with multiple myeloma with normal performance status.老年综合评估发现体能状况正常的多发性骨髓瘤患者存在功能缺陷。
J Geriatr Oncol. 2022 Mar;13(2):182-189. doi: 10.1016/j.jgo.2021.08.004. Epub 2021 Aug 11.
4
Cancer Statistics, 2021.癌症统计数据，2021.
CA Cancer J Clin. 2021 Jan;71(1):7-33. doi: 10.3322/caac.21654. Epub 2021 Jan 12.
5
Effects of Breast Cancer Adjuvant Chemotherapy Regimens on Expression of the Aging Biomarker, .乳腺癌辅助化疗方案对衰老生物标志物表达的影响，. （原文结尾处标点不完整，翻译可能会有些生硬，你可检查下原文是否完整。）
JNCI Cancer Spectr. 2020 Dec 18;4(6):pkaa082. doi: 10.1093/jncics/pkaa082. eCollection 2020 Dec.
6
Accelerated aging among childhood, adolescent, and young adult cancer survivors is evidenced by increased expression of p16 and frailty.儿童、青少年和青年癌症幸存者存在加速衰老现象，其表现为 p16 表达增加和虚弱。
Cancer. 2020 Nov 15;126(22):4975-4983. doi: 10.1002/cncr.33112. Epub 2020 Aug 24.
7
Ready for prime time: role for geriatric assessment to improve quality of care in hematology practice.准备好进入黄金时段：老年评估在改善血液学实践中的护理质量中的作用。
Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):53-58. doi: 10.1182/hematology.2019001299.
8
Frailty Index Developed From a Cancer-Specific Geriatric Assessment and the Association With Mortality Among Older Adults With Cancer.基于癌症特异性老年评估开发的虚弱指数与老年癌症患者死亡率的相关性。
J Natl Compr Canc Netw. 2017 Jul;15(7):894-902. doi: 10.6004/jnccn.2017.0122.
9
Chemotherapy and Stem Cell Transplantation Increase p16 Expression, a Biomarker of T-cell Aging.化疗和干细胞移植会增加p16的表达，p16是T细胞衰老的生物标志物。
EBioMedicine. 2016 Sep;11:227-238. doi: 10.1016/j.ebiom.2016.08.029. Epub 2016 Aug 21.
10
Autologous hematopoietic stem cell transplant induces the molecular aging of T-cells in multiple myeloma.自体造血干细胞移植会引发多发性骨髓瘤中T细胞的分子衰老。
Bone Marrow Transplant. 2015 Oct;50(10):1379-81. doi: 10.1038/bmt.2015.143. Epub 2015 Jun 29.

Association of p16(INK4a), a biomarker of cellular senescence, with receipt of therapy and frailty status among adults with plasma cell disorders.

作者信息

Jensen Christopher E, Deal Allison M, Srikanth Shweta, Nyrop Kirsten A, Mitin Natalia, LeBlanc Matthew R, Muss Hyman B, Rubinstein Samuel M, Tuchman Sascha A, Lichtman Eben I

机构信息

University of North Carolina School of Medicine, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.

出版信息

J Geriatr Oncol. 2025 May;16(4):102174. doi: 10.1016/j.jgo.2024.102174. Epub 2024 Dec 20.

DOI:10.1016/j.jgo.2024.102174
PMID:39706780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12078013/
Abstract
摘要