Department of Endocrinology, Affiliated Dongguan Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, China.
Endokrynol Pol. 2022;73(1):157-162. doi: 10.5603/EP.a2022.0004. Epub 2022 Feb 4.
Thyrotoxic myopathy is hyperthyroidism accompanied by muscle lesions. It is recognized as the general term for a group of symptoms with several main manifestations of several hyperthyroidism patients in the course (e.g. muscle weakness, muscle paralysis, or pain). From the clinical perspective, it may only be manifested as muscle-related symptoms. The symptoms of high metabolic syndrome (e.g. thyrotoxicosis) are absent, obscured, or relatively delayed, so it can be easily misdiagnosed. Accordingly, patients experiencing the first symptom of myopathy should concentrate on the possibility of thyrotoxic myopathy. Given the clinical characteristics, thyrotoxic myopathy can be devided into chronic thyrotoxic myopathy, thyrotoxicosis with periodic paralysis, acute thyrotoxic myopathy, hyperthyroidism with myasthenia gravis, as well as infiltrating exophthalmos with ophthalmoplegia. In this paper, we review thyrotoxic myopathy research status, diagnoses, and treatments.
甲状腺毒症性肌病是指甲状腺功能亢进伴有肌肉病变。它被认为是一组以多种主要表现为特征的症状的统称，这些表现出现在一些甲状腺功能亢进患者的病程中（例如肌肉无力、肌肉瘫痪或疼痛）。从临床角度来看，它可能仅表现为与肌肉相关的症状。高代谢综合征（如甲状腺毒症）的症状缺失、被掩盖或相对延迟，因此容易误诊。因此，出现肌病首发症状的患者应集中考虑甲状腺毒症性肌病的可能性。根据临床特点，甲状腺毒症性肌病可分为慢性甲状腺毒症性肌病、周期性麻痹伴甲状腺毒症、急性甲状腺毒症性肌病、甲状腺功能亢进合并重症肌无力，以及浸润性突眼伴眼肌麻痹。本文就甲状腺毒症性肌病的研究现状、诊断和治疗进行综述。
