Key Laboratory of Environment Correlative Dietology (Ministry of Education), College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China.
J Sci Food Agric. 2022 Aug 30;102(11):4532-4541. doi: 10.1002/jsfa.11808. Epub 2022 Mar 4.
Artemisia selengensis Turcz. (AST) is a common edible and medicinal herb possessing extensive biological activities and various health-promoting functions. However, the anti-aging effects of AST have been neglected. This work evaluated the effects of AST leaf extract (ASTE) on stress tolerance and longevity in Caenorhabditis elegans.
ASTE treatment enhanced stress resistance and significantly extended the lifespan of C. elegans. Moreover, ASTE prolonged the healthspan by increasing body bending and pharyngeal pumping rates, and by reducing the intestinal lipofuscin level and accumulation of intracellular reactive oxygen species (ROS). Caffeoylquinic acids in ASTE, especially dicaffeoylquinic acids, were the major components responsible for these benefits. The mechanism underlying the anti-aging effect of ASTE occurred by activating insulin/insulin-like growth factor, SIR-2.1 signaling and mitochondrial dysfunction pathways, which in turn induced the activity of the transcription factors DAF-16/FOXO and SKN-1/Nrf2.
These findings provide direct evidence for the anti-aging effects of AST and reveal its potential on promoting healthy aging. © 2022 Society of Chemical Industry.
黄花蒿（Artemisia selengensis Turcz.）是一种常见的食用和药用草本植物，具有广泛的生物活性和多种促进健康的功能。然而，黄花蒿的抗衰老作用一直被忽视。本研究评估了黄花蒿叶提取物（ASTE）对秀丽隐杆线虫应激耐受和寿命的影响。
ASTE 处理增强了秀丽隐杆线虫的应激抗性，并显著延长了其寿命。此外，ASTE 通过增加身体弯曲和咽部抽吸率，降低肠道脂褐素水平和细胞内活性氧（ROS）积累，延长了秀丽隐杆线虫的健康寿命。ASTE 中的咖啡酰奎宁酸，特别是二咖啡酰奎宁酸，是其发挥这些益处的主要成分。ASTE 抗衰老作用的机制是通过激活胰岛素/胰岛素样生长因子、SIR-2.1 信号和线粒体功能障碍途径，从而诱导转录因子 DAF-16/FOXO 和 SKN-1/Nrf2 的活性。
这些发现为黄花蒿的抗衰老作用提供了直接证据，并揭示了其促进健康衰老的潜力。© 2022 英国化学学会。
