Magil A B, McFadden D, Rae A
Hum Pathol. 1986 Feb;17(2):192-4. doi: 10.1016/s0046-8177(86)80293-3.
Well-documented cases of systemic lupus erythematosus (SLE) with thrombotic microangiopathy (TMA) are rare. Renal biopsy in a 25-year-old woman with SLE who was in renal failure demonstrated proliferative lupus glomerulonephritis with arteriolar thrombosis and the arterial intimal changes of TMA. No staining of vessels for immunoglobulins or complement was found by direct immunofluorescence. Fibrillar and flocculent deposits were seen in the widened and rarefied subendothelial space in a small artery and two glomeruli, one of which also contained electron-dense deposits. The vascular findings, which are those of TMA, are distinct from the immune complex vasculopathy of SLE.
有充分记录的系统性红斑狼疮（SLE）合并血栓性微血管病（TMA）的病例很少见。一名25岁处于肾衰竭期的SLE女性患者的肾活检显示为增殖性狼疮性肾小球肾炎，伴有小动脉血栓形成和TMA的动脉内膜改变。直接免疫荧光检查未发现血管有免疫球蛋白或补体染色。在一条小动脉和两个肾小球的增宽和稀疏的内皮下间隙中可见纤维状和絮状沉积物，其中一个肾小球还含有电子致密沉积物。这些血管表现符合TMA，与SLE的免疫复合物血管病不同。
