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加拿大和美国青少年及青年人群中使用大麻制品和给药途径的流行率和使用情况:系统评价。

Prevalence and use of cannabis products and routes of administration among youth and young adults in Canada and the United States: A systematic review.

机构信息

School of Public Health Sciences, University of Waterloo, Canada.

Addiction and Mental Health Group (AIM), Department of Psychology, University of Bath, UK.

出版信息

Addict Behav. 2022 Jun;129:107258. doi: 10.1016/j.addbeh.2022.107258. Epub 2022 Jan 22.

Abstract

BACKGROUND

The current systematic review aimed to summarize the literature on the prevalence of routes of administration and cannabis products used among youth and young adults in Canada and the United States (US).

METHODS

Five academic databases were searched in April 2020 and February 2021. Peer-reviewed articles were included if they were a population-based quantitative observational study describing the prevalence of a cannabis product or route of administration among youth and young adults in Canada or the US. Risk of bias was assessed using Hoy and colleagues' risk of bias assessment tool. A narrative review was conducted.

RESULTS

Twenty-six studies were identified for the following routes of administration: smoking (n = 16), vaping (n = 21), dabbing (n = 3), oral (n = 13), topical (n = 1); and products: dried flower (n = 2), and concentrates (n = 8). Smoking had the highest prevalence rates among youth and young adults; however, rates of use appeared to reduce over time. Conversely, prevalence of vaping appeared to increase over time. Fewer studies focused on oral or dabbed cannabis but those that did reported prevalence estimates of approximately a third among recent cannabis consumers.

DISCUSSION

The heterogeneity of cannabis routes of administration restricted our ability to collate average prevalence estimates. In jurisdictions where non-medical cannabis is legal, policymakers should provide guidance and education to youth on each type of product and routes of administration.

OTHER

Funding for this study was provided by a Canadian Institutes of Health Research (PJT-153342). The current review was registered with PROSPERO (CRD42020169275).

摘要

背景

本系统评价旨在总结加拿大和美国青少年和年轻成年人使用的给药途径和大麻制品的文献。

方法

2020 年 4 月和 2021 年 2 月,在五个学术数据库中进行了检索。如果是描述加拿大或美国青少年和年轻成年人中某种大麻制品或给药途径流行率的基于人群的定量观察性研究,则纳入同行评议文章。使用 Hoy 等人的偏倚风险评估工具评估偏倚风险。进行了叙述性综述。

结果

确定了以下给药途径的 26 项研究:吸烟(n=16)、蒸气吸入(n=21)、涂擦(n=3)、口服(n=13)、局部使用(n=1);以及制品:干花(n=2)和浓缩物(n=8)。吸烟在青少年和年轻成年人中的流行率最高;然而,使用率似乎随着时间的推移而降低。相反,蒸气吸入的流行率似乎随着时间的推移而增加。较少的研究集中于口服或涂擦大麻,但这些研究报告的最近大麻使用者中的流行率估计约为三分之一。

讨论

大麻给药途径的异质性限制了我们汇总平均流行率估计的能力。在非医用大麻合法的司法管辖区,政策制定者应向青年提供关于每种产品和给药途径的指导和教育。

其他

本研究的资金由加拿大卫生研究院提供(PJT-153342)。当前的综述在 PROSPERO(CRD42020169275)中注册。

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