Ahlborg G, Wahren J, Felig P
J Clin Invest. 1986 Mar;77(3):690-9. doi: 10.1172/JCI112363.
Splanchnic and peripheral exchange of glucose and gluconeogenic substrates was examined in 12 healthy subjects during 2 h of arm or leg exercise on a bicycle ergometer and during a 40-min postexercise recovery period. The work intensity corresponded to 30% of the maximal pulmonary oxygen uptake. The regional exchange of substrates was evaluated using catheter technique and indicator dilution methods for blood flow measurements. Our findings indicate that prolonged arm exercise as compared with exercise with the legs results in a greater increase in heart rate (25-40%) and a more marked reduction in splanchnic blood flow (10-30%) as well as higher arterial concentrations of lactate, free fatty acids, and catecholamines. The respiratory exchange ratio was consistently higher with arm exercise. In addition, arm exercise results in a greater fractional extraction and utilization of glucose by exercising muscle as well as a greater hepatic gluconeogenesis from lactate and glycerol. During recovery from prolonged arm exercise, leg muscle becomes an important site of lactate release to the splanchnic bed, despite a lack of net glucose uptake by the leg. Simultaneously, arm muscle shows an increase in glucose uptake in the absence of a net release of lactate. These coincident but discordant processes in the leg and arm during recovery suggest the occurrence of a redistribution of muscle glycogen from previously resting (leg) muscle to previously exercising (arm) muscle.
在12名健康受试者中，使用自行车测力计进行2小时的手臂或腿部运动，并在运动后40分钟的恢复期内，研究了内脏和外周葡萄糖及糖异生底物的交换情况。工作强度相当于最大肺摄氧量的30%。使用导管技术和指示剂稀释法测量血流量，评估底物的区域交换情况。我们的研究结果表明，与腿部运动相比，长时间的手臂运动导致心率升高幅度更大（25%-40%），内脏血流量下降更明显（10%-30%），同时动脉血中乳酸、游离脂肪酸和儿茶酚胺的浓度更高。手臂运动时呼吸交换率始终更高。此外，手臂运动导致运动肌肉对葡萄糖的分数提取和利用率更高，以及肝脏从乳酸和甘油生成葡萄糖的能力更强。在长时间手臂运动后的恢复过程中，尽管腿部没有净葡萄糖摄取，但腿部肌肉成为向内脏床释放乳酸的重要部位。同时，手臂肌肉在没有乳酸净释放的情况下葡萄糖摄取增加。恢复过程中腿部和手臂这些同时发生但不一致的过程表明，肌肉糖原从先前静止的（腿部）肌肉重新分布到先前运动的（手臂）肌肉。
