Tomić-Spirić Vesna, Kovačević Gordana, Marinković Jelena, Janković Janko, Ćirković Anđa, Đerić Ana Milošević, Relić Nenad, Janković Slavenka
Department of Internal Medicine, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Clinic for Allergology and Immunology, Clinical Centre of Serbia, Belgrade, Serbia.
J Res Med Sci. 2021 Nov 29;26:109. doi: 10.4103/jrms.JRMS_6_20. eCollection 2021.
Strong epidemiological evidence suggests that air pollution plays a significant role in the exacerbation of allergic respiratory diseases. This study aimed to assess the potential relationship between daily levels of sulfur dioxide (SO) and emergency department (ED) visits for allergic diseases.
Data regarding ED visits for allergic respiratory diseases were routinely collected from the EDs in the Zlatibor district, and the General Hospital, Užice. The daily average concentrations of SO were obtained from the regional automatic air quality monitoring stations. All data were collected from June 2012 to July 2014. A time-stratified case-crossover design was used. Crude odds ratios (ORs) and ORs adjusted for weather conditions were calculated using conditional logistic regression.
Statistically significant associations were seen between 0-day lagged exposure to SO and ED visits for all allergic diseases (OR = 1.62; 95% confidence interval [CI]: 1.05-2.48; = 0.028) and between 2-day lagged exposure to SO and ED visits for asthma with allergic rhinitis (OR = 2.00; 95% CI: 1.03-3.88; = 0.042). These results were adjusted for temperature, temperature, and humidity.
Our results suggest that short-term exposure to SO conferred an increased risk of ED visits for allergic respiratory diseases, particularly for asthma with concomitant allergic rhinitis.
有力的流行病学证据表明，空气污染在过敏性呼吸道疾病的加重中起重要作用。本研究旨在评估二氧化硫（SO）的每日水平与过敏性疾病急诊就诊之间的潜在关系。
从兹拉蒂博尔区和乌日采总医院的急诊科常规收集过敏性呼吸道疾病急诊就诊的数据。SO的日平均浓度来自区域自动空气质量监测站。所有数据均在2012年6月至2014年7月期间收集。采用时间分层病例交叉设计。使用条件逻辑回归计算粗比值比（OR）和经天气条件调整的OR。
在0天滞后暴露于SO与所有过敏性疾病的急诊就诊之间（OR = 1.62；95%置信区间[CI]：1.05 - 2.48；P = 0.028）以及在2天滞后暴露于SO与伴有过敏性鼻炎的哮喘急诊就诊之间（OR = 2.00；95%CI：1.03 - 3.88；P = 0.042）观察到具有统计学意义的关联。这些结果针对温度、气温和湿度进行了调整。
我们的结果表明，短期暴露于SO会增加过敏性呼吸道疾病急诊就诊的风险，特别是伴有过敏性鼻炎的哮喘。
