Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, China.
Department of Pediatric Intensive Care Unit, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, China.
Dis Markers. 2022 Jan 27;2022:3893653. doi: 10.1155/2022/3893653. eCollection 2022.
The effect of serum magnesium on the prognosis of children with sepsis in the pediatric intensive care unit (PICU) is unclear. This study was designed to assess the risk of inpatient mortality for children with sepsis in the PICU based on serum magnesium levels at admission.
We collected patients' clinical information from the Pediatric Intensive Care database and then performed locally weighted scatterplot smoothing (LOWESS) analysis, Kaplan-Meier analysis, and multivariate logistic regression to determine the relationship between admission serum magnesium and inpatient mortality in children with sepsis.
A total of 974 critically ill children with sepsis were included, with 246 patients in the hypomagnesemia group, 666 in the normal group, and 62 in the hypermagnesemia group. The chi-square test suggested that the hypermagnesemia group had higher in-hospital mortality than the normal group (14.5% vs. 2.4%, < 0.001). Kaplan-Meier curves revealed that the 30-day overall survival rate was lower in the hypermagnesaemia group than in the normal group ( < 0.001). The multivariate logistic regression model revealed that hypermagnesaemia was a risk factor related to inpatient mortality (odds ratio 4.22, 95% CI 1.55-11.50), while hypomagnesaemia was not a significant factor for inpatient mortality (odds ratio 0.78, 95% CI 0.26-2.32).
Hypermagnesaemia, but not hypomagnesaemia, is a predictor of inpatient mortality in critically ill children with sepsis.
血清镁对儿科重症监护病房（PICU）中脓毒症患儿预后的影响尚不清楚。本研究旨在评估入院时血清镁水平对 PICU 中脓毒症患儿住院病死率的风险。
我们从儿科重症监护数据库中收集患者的临床信息，然后进行局部加权散点平滑（LOWESS）分析、Kaplan-Meier 分析和多变量逻辑回归，以确定入院时血清镁与脓毒症患儿住院病死率之间的关系。
共纳入 974 例危重症脓毒症患儿，其中低镁血症组 246 例，正常组 666 例，高镁血症组 62 例。卡方检验提示高镁血症组住院病死率高于正常组（14.5%比 2.4%，<0.001）。Kaplan-Meier 曲线显示高镁血症组 30 天总生存率低于正常组（<0.001）。多变量逻辑回归模型显示高镁血症是与住院病死率相关的危险因素（比值比 4.22，95%CI 1.55-11.50），而低镁血症不是住院病死率的显著因素（比值比 0.78，95%CI 0.26-2.32）。
高镁血症而非低镁血症是危重症脓毒症患儿住院病死率的预测因素。
