Zang Rina, Zhang Yayu, Zhang Hanshuo, Zhang Xueyi, Lv Yuening, Li Dan
Department of Neonatology, Affiliated Hospital of Inner Mongolia Medical University, Huhhot, China.
Front Pediatr. 2022 Jan 21;9:803143. doi: 10.3389/fped.2021.803143. eCollection 2021.
In recent years, vitamin D in the occurrence of lung diseases has gradually become a hot topic. Although the role of vitamin D in normal lung development has been confirmed, the correlation between vitamin D level and neonatal respiratory distress syndrome (NRDS) is not clear.
To evaluate the association between vitamin D level and NRDS.
We performed a comprehensive search of the following electronic databases: PubMed, Embase, Cochrane Library, Web of Science, and China National Knowledge Infrastructure (CNKI). Literature screening and quality assessment were performed according to inclusion and exclusion criteria. The Newcastle-Ottawa Scale was used to assess the methodological components of each study, and Stata 15.1 software to perform the Meta-analysis.
A total of nine case-control studies were included, with 653 infants with NRDS and 501 infants without NRDS. The Meta-analysis showed no heterogeneity across all studies(I=0.0%, P=0.583). The fixed-effect model showed that 25 hydroxy vitamin D level of children in the NRDS group was significantly lower than that of the non-NRDS group(SMD = -0.51, 95%CI: -0.63 to -0.39, ≤ 0.05).
This systematic review and meta-analysis study suggests that vitamin D deficiency is very likely to be a high-risk factor of NRDS, and reasonable vitamin D supplementation during pregnancy and after birth is of great significance.
近年来，维生素D在肺部疾病发生中的作用逐渐成为热门话题。尽管维生素D在正常肺发育中的作用已得到证实，但维生素D水平与新生儿呼吸窘迫综合征（NRDS）之间的相关性尚不清楚。
评估维生素D水平与NRDS之间的关联。
我们对以下电子数据库进行了全面检索：PubMed、Embase、Cochrane图书馆、Web of Science和中国知网（CNKI）。根据纳入和排除标准进行文献筛选和质量评估。采用纽卡斯尔-渥太华量表评估每项研究的方法学组成部分，并使用Stata 15.1软件进行Meta分析。
共纳入9项病例对照研究，其中653例NRDS患儿和501例非NRDS患儿。Meta分析显示所有研究间无异质性（I=0.0%，P=0.583）。固定效应模型显示，NRDS组儿童的25羟维生素D水平显著低于非NRDS组（标准化均数差=-0.51，95%置信区间：-0.63至-0.39，P≤0.05）。
这项系统评价和Meta分析研究表明，维生素D缺乏很可能是NRDS的高危因素，孕期和产后合理补充维生素D具有重要意义。
