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1
What We Know and Don't Know About Lyme Disease.我们对莱姆病的了解和不了解。
Front Public Health. 2022 Jan 21;9:819541. doi: 10.3389/fpubh.2021.819541. eCollection 2021.
2
[Early diagnosis of Lyme arthritis].[莱姆关节炎的早期诊断]
Z Rheumatol. 2005 Nov;64(8):531-7. doi: 10.1007/s00393-005-0793-6.
3
Diagnostic challenges of early Lyme disease: lessons from a community case series.早期莱姆病的诊断挑战:来自一个社区病例系列的经验教训。
BMC Infect Dis. 2009 Jun 1;9:79. doi: 10.1186/1471-2334-9-79.
4
Lyme disease.莱姆病
Clin Infect Dis. 2000 Aug;31(2):533-42. doi: 10.1086/313982. Epub 2000 Sep 14.
5
Polymerase chain reaction in diagnosis of Borrelia burgdorferi infections and studies on taxonomic classification.聚合酶链反应在伯氏疏螺旋体感染诊断及分类学研究中的应用
APMIS Suppl. 2002(105):1-40.
6
Lyme disease--part II: clinical features and treatment.莱姆病——第二部分:临床特征与治疗
Cutis. 2002 Jun;69(6):443-8.
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Lyme borreliosis: from pathogenesis to diagnosis and treatment.莱姆病:从发病机制到诊断与治疗
Clin Dev Immunol. 2012;2012:231657. doi: 10.1155/2012/231657. Epub 2012 Sep 13.
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Cimetidine as a novel adjunctive treatment for early stage Lyme disease.西咪替丁作为一种新型辅助治疗早期莱姆病的方法。
Med Hypotheses. 2019 Jul;128:94-100. doi: 10.1016/j.mehy.2016.03.015. Epub 2016 Apr 9.
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Management of Lyme disease refractory to antibiotic therapy.抗生素治疗难治性莱姆病的管理。
Rheum Dis Clin North Am. 1995 Feb;21(1):217-30.
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Orthopaedic manifestations of Lyme disease.莱姆病的骨科表现。
Orthop Rev. 1994 May;23(5):395-400.

引用本文的文献

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Lyme disease and Whipple's disease: a comprehensive review for the rheumatologist.莱姆病和惠普尔病:风湿病医生的综合综述。
Adv Rheumatol. 2024 Mar 4;64(1):16. doi: 10.1186/s42358-024-00359-x.
2
Identifying Potential Lyme Disease Cases Using Self-Reported Worldwide Tweets: Deep Learning Modeling Approach Enhanced With Sentimental Words Through Emojis.利用自我报告的全球推文识别潜在莱姆病病例:通过表情符号增强带有情感词汇的深度学习模型。
J Med Internet Res. 2023 Oct 16;25:e47014. doi: 10.2196/47014.
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Access to Care in Lyme Disease: Clinician Barriers to Providing Care.莱姆病的医疗服务可及性:临床医生提供医疗服务的障碍
Healthcare (Basel). 2022 Sep 27;10(10):1882. doi: 10.3390/healthcare10101882.
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Large-Scale Sequencing of for the Construction of Pan-Genomic-Based Diagnostics.基于全基因组的诊断构建的大规模测序。
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本文引用的文献

1
A murine model of Lyme disease demonstrates that Borrelia burgdorferi colonizes the dura mater and induces inflammation in the central nervous system.莱姆病的小鼠模型表明,伯氏疏螺旋体定殖于硬脑膜并在中枢神经系统中引发炎症。
PLoS Pathog. 2021 Feb 1;17(2):e1009256. doi: 10.1371/journal.ppat.1009256. eCollection 2021 Feb.
2
Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding.通过蜱叮咬感染伯氏疏螺旋体的非人灵长类动物表现出可变的症状、多样的血清反应性以及治疗后病原体持续存在的情况。
PLoS One. 2017 Dec 13;12(12):e0189071. doi: 10.1371/journal.pone.0189071. eCollection 2017.
3
Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease.随机试验:更长时间治疗莱姆病相关症状的疗效。
N Engl J Med. 2016 Mar 31;374(13):1209-20. doi: 10.1056/NEJMoa1505425.
4
Borrelia burgdorferi, the Causative Agent of Lyme Disease, Forms Drug-Tolerant Persister Cells.莱姆病的病原体伯氏疏螺旋体可形成耐药性持留菌。
Antimicrob Agents Chemother. 2015 Aug;59(8):4616-24. doi: 10.1128/AAC.00864-15. Epub 2015 May 26.
5
Chronic Lyme disease.慢性莱姆病
Infect Dis Clin North Am. 2015 Jun;29(2):325-40. doi: 10.1016/j.idc.2015.02.006.
6
Drug combinations against Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline.联合用药消除体外伯氏疏螺旋体持续感染:达托霉素联合头孢哌酮和多西环素可实现完全清除。
PLoS One. 2015 Mar 25;10(3):e0117207. doi: 10.1371/journal.pone.0117207. eCollection 2015.
7
Microbiology. Persisters unmasked.微生物学。揭示的持留菌。
Science. 2015 Jan 2;347(6217):30-2. doi: 10.1126/science.1262033.
8
CD4+ T cells promote antibody production but not sustained affinity maturation during Borrelia burgdorferi infection.在伯氏疏螺旋体感染期间,CD4 + T细胞促进抗体产生,但不促进持续的亲和力成熟。
Infect Immun. 2015 Jan;83(1):48-56. doi: 10.1128/IAI.02471-14. Epub 2014 Oct 13.
9
Xenodiagnosis to detect Borrelia burgdorferi infection: a first-in-human study.用于检测伯氏疏螺旋体感染的异种诊断:一项人体首例研究。
Clin Infect Dis. 2014 Apr;58(7):937-45. doi: 10.1093/cid/cit939. Epub 2014 Feb 11.
10
Resurgence of persisting non-cultivable Borrelia burgdorferi following antibiotic treatment in mice.抗生素治疗后小鼠体内持续存在的不可培养的伯氏疏螺旋体复苏
PLoS One. 2014 Jan 23;9(1):e86907. doi: 10.1371/journal.pone.0086907. eCollection 2014.

我们对莱姆病的了解和不了解。

What We Know and Don't Know About Lyme Disease.

机构信息

Consultant, Infectious Diseases, Falmouth Hospital, Falmouth, MA, United States.

出版信息

Front Public Health. 2022 Jan 21;9:819541. doi: 10.3389/fpubh.2021.819541. eCollection 2021.

DOI:10.3389/fpubh.2021.819541
PMID:35127630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8813852/
Abstract

We know the cause of Lyme disease. We know that the bacteria can be found in the initial rash, and occasionally in the blood in the subsequent 2-3 months, but after then, its subsequent location is unknown. Whereas diagnosis and treatment of early Lyme disease is generally straightforward, the etiology of relapsing or persisting symptoms is yet to be defined, and presents clinical challenges. There are no current tests to determine if the infection is still present or absent, thus complicating diagnosis and treatment. Presented here are approaches to the diagnosis and treatment of persisting Lyme disease, based on available published information, and the experience of the author.

摘要

我们知道莱姆病的病因。我们知道在初始皮疹中可以发现这种细菌,并且在随后的 2-3 个月中偶尔也可以在血液中发现,但此后,其后续位置未知。尽管早期莱姆病的诊断和治疗通常很简单,但复发或持续症状的病因尚未确定,这带来了临床挑战。目前尚无确定感染是否仍然存在或不存在的测试,因此使诊断和治疗变得复杂。根据现有发表的信息和作者的经验,本文介绍了持续莱姆病的诊断和治疗方法。