新型冠状病毒肺炎（COVID-19）孕妇的肺部超声征象及其与临床症状的相关性：“PINK-CO”观察性研究
Lung Ultrasound Signs and Their Correlation With Clinical Symptoms in COVID-19 Pregnant Women: The "PINK-CO" Observational Study.
作者信息
Vetrugno Luigi, Sala Alessia, Orso Daniele, Meroi Francesco, Fabbro Sebastiano, Boero Enrico, Valent Francesca, Cammarota Gianmaria, Restaino Stefano, Vizzielli Giuseppe, Girometti Rossano, Merelli Maria, Tascini Carlo, Bove Tiziana, Driul Lorenza
机构信息
Department of Medicine, University of Udine, Udine, Italy.
Department of Anesthesia and Intensive Care Medicine, ASUFC University-Hospital of Friuli Centrale, Udine, Italy.
出版信息
Front Med (Lausanne). 2022 Jan 21;8:768261. doi: 10.3389/fmed.2021.768261. eCollection 2021.
OBJECTIVE
To analyze the application of lung ultrasound (LUS) diagnostic approach in obstetric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and compare LUS score and symptoms of the patients.
DESIGN
A single-center observational retrospective study from October 31, 2020 to March 31, 2021.
SETTING
Department of Ob/Gyn at the University-Hospital of Udine, Italy.
PARTICIPANTS
Pregnant women with SARS-CoV-2 diagnosed with reverse transcription-PCR (RT-PCR) swab test were subdivided as symptomatic and asymptomatic patients with COVID-19.
EXPOSURE
Lung ultrasound evaluation both through initial evaluation upon admission and through serial evaluations.
MAIN OUTCOME
Reporting LUS findings and LUS score characteristics.
RESULTS
Symptomatic patients with COVID-19 showed a higher LUS (median 3.5 vs. 0, < 0.001). LUS was significantly correlated with COVID-19 biomarkers as C-reactive protein (CPR; = 0.011), interleukin-6 ( = 0.013), and pro-adrenomedullin ( = 0.02), and inversely related to arterial oxygen saturation ( = 0.004). The most frequent ultrasound findings were focal B lines (14 vs. 2) and the light beam (9 vs. 0).
CONCLUSION
Lung ultrasound can help to manage pregnant women with SARS-CoV-2 infection during a pandemic surge.
STUDY REGISTRATION
ClinicalTrials.gov, NCT04823234. Registered on March 29, 2021.
目的
分析肺部超声（LUS）诊断方法在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的产科患者中的应用，并比较患者的LUS评分和症状。
设计
一项于2020年10月31日至2021年3月31日进行的单中心观察性回顾性研究。
地点
意大利乌迪内大学医院妇产科。
参与者
通过逆转录聚合酶链反应（RT-PCR）拭子检测确诊为SARS-CoV-2感染的孕妇被分为有症状和无症状的COVID-19患者。
暴露因素
通过入院时的初始评估和连续评估进行肺部超声评估。
主要结局
报告LUS检查结果和LUS评分特征。
结果
有症状的COVID-19患者的LUS更高（中位数3.5对0，<0.001）。LUS与COVID-19生物标志物如C反应蛋白（CPR；=0.011）、白细胞介素-6（=0.013）和前肾上腺髓质素（=0.02）显著相关，与动脉血氧饱和度呈负相关（=0.004）。最常见的超声检查结果是局灶性B线（14对2）和光束征（9对0）。
结论
在大流行高峰期间，肺部超声有助于管理感染SARS-CoV-2的孕妇。
研究注册
ClinicalTrials.gov，NCT04823234。于2021年3月29日注册。
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