Feng Jiaqi, Li Jia, Li Yixuan, Jin Yuyang, Du Fang, Chen Xiaoxiang
Department of Rheumatology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Front Med (Lausanne). 2022 Jan 21;8:816422. doi: 10.3389/fmed.2021.816422. eCollection 2021.
To investigate the association of D-dimer with gut inflammation in spondyloarthritis (SpA).
Sixty-five patients with SpA and 70 healthy controls were included. Demographic, clinical, and laboratory parameters were collected. The differences of clinical and laboratory parameters were compared between patients with SpA and healthy controls, and between patients with SpA, with and without gut inflammation. The associations of D-dimer with laboratory data were analyzed. The predictive value of D-dimer was obtained by a receiver operator characteristic (ROC) curve analysis. The independent risk factors for gut inflammation in SpA were investigated by binary logistic regression analysis.
Patients with SpA had higher D-dimer than healthy controls = 0.016). D-dimer was positively correlated with platelet (PLT), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), and negatively correlated with hemoglobin (Hb). Besides, significant differences were observed in D-dimer between SpA patients with and without gut inflammation ( < 0.001). Furthermore, SpA patients with gut inflammation were more likely to have peripheral joint involvement than those without gut inflammation ( < 0.001). The AUC of D-dimer was 0.865 at cut-off value of 0.29 mg/L, with a sensitivity of 82.6%, and a specificity of 81%. Elevated D-dimer (OR = 15.451, 95% CI: 3.030-78.780, = 0.001) was independently associated with gut inflammation in SpA.
D-dimer may be a potential biomarker for identifying SpA patients with gut inflammation.
探讨D-二聚体与脊柱关节炎（SpA）肠道炎症的相关性。
纳入65例SpA患者和70例健康对照。收集人口统计学、临床和实验室参数。比较SpA患者与健康对照之间，以及有和无肠道炎症的SpA患者之间临床和实验室参数的差异。分析D-二聚体与实验室数据的相关性。通过受试者工作特征（ROC）曲线分析获得D-二聚体的预测价值。采用二元逻辑回归分析探讨SpA肠道炎症的独立危险因素。
SpA患者的D-二聚体高于健康对照（ = 0.016）。D-二聚体与血小板（PLT）、红细胞沉降率（ESR）和C反应蛋白（CRP）呈正相关，与血红蛋白（Hb）呈负相关。此外，有和无肠道炎症的SpA患者之间D-二聚体存在显著差异（ < 0.001）。此外，有肠道炎症的SpA患者比无肠道炎症的患者更易出现外周关节受累（ < 0.001）。D-二聚体的曲线下面积（AUC）在临界值为0.29 mg/L时为0.865，灵敏度为82.6%，特异度为81%。D-二聚体升高（比值比[OR] = 15.451，95%置信区间[CI]：3.030 - 78.780， = 0.001）与SpA肠道炎症独立相关。
D-二聚体可能是识别有肠道炎症的SpA患者的潜在生物标志物。
