Mattath Mohamed Nabeel, Ghosh Debasis, Pratihar Sumon, Shi Shuo, Govindaraju Thimmaiah
Bioorganic Chemistry Laboratory, New Chemistry Unit and School of Advanced Materials (SAMat), Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bengaluru, Karnataka 560064, India.
School of Chemical Science and Engineering, Tongji University, 1239 Siping Rd, Shanghai, 200092, PR China.
ACS Omega. 2022 Jan 21;7(4):3167-3176. doi: 10.1021/acsomega.1c06464. eCollection 2022 Feb 1.
Nucleic acid-based architectures have opened up numerous opportunities for basic and applied research in the field of DNA nanotechnology. The scheme of molecular architectonics of nucleic acids exploits conventional and unconventional base pairing interactions to integrate molecular partners in constructing functional molecular architectures and devices. The pH-responsive functional nucleic acid systems and devices have gained interest in diagnostics and therapeutics because of their biocompatibility and structural programmability. In this Mini-Review, we discuss recent advancements in the area of nucleic acid architectonics with a special emphasis on pH-driven molecular systems including molecular and nanoarchitectures, templated architectures and nanoclusters, nanomachines, hydrogels, targeted bioimaging, and drug delivery architectures. Finally, the Mini-Review is concluded by highlighting the challenges and opportunities for future developments.
基于核酸的结构为DNA纳米技术领域的基础研究和应用研究带来了众多机遇。核酸分子建筑学方案利用传统和非常规碱基配对相互作用，在构建功能性分子结构和装置时整合分子伙伴。pH响应性功能核酸系统和装置因其生物相容性和结构可编程性而在诊断和治疗领域受到关注。在本综述中，我们讨论了核酸建筑学领域的最新进展，特别强调了pH驱动的分子系统，包括分子和纳米结构、模板化结构和纳米簇、纳米机器、水凝胶、靶向生物成像和药物递送结构。最后，通过强调未来发展的挑战和机遇来结束本综述。
