The Institute for the Study of Fertility, Tel Aviv University, Tel Aviv, Israel.
Israel Academic College, Ramat Gan, Israel.
Int J Gynaecol Obstet. 2022 Jul;158(1):116-120. doi: 10.1002/ijgo.14135. Epub 2022 Feb 26.
To examine the effect of the BNT162b, mRNA, SARS-CoV-2 virus vaccine on sperm quality.
This was a prospective cohort study conducted on sperm donors at the sperm bank of a tertiary, university affiliated medical center. All sperm donors donated sperm repeatedly and the average sperm parameters of all available samples were compared before and after receiving the SARS-CoV-2 vaccine. Each donor served as his own control. For all participants, at-least one sperm sample was received 72 days after completing the second vaccine. Main outcome measures included total sperm count, total motile count and percent of motile sperm.
A total of 898 sperm samples from 33 sperm donors that were vaccinated with the Pfizer BNT162b, mRNA, SARS-CoV-2 virus vaccine were analyzed, 425 samples were received before the vaccine, while 473 samples were received after vaccination. Total sperm count and total motile count increased after the second vaccine compared to samples before vaccination. Percent of motile sperm did not change after vaccine.
The Pfizer BNT162b, SARS-CoV-2 vaccine has no deleterious effect on sperm quality. Patients and physicians should be counseled accordingly.
研究 BNT162b mRNA SARS-CoV-2 病毒疫苗对精子质量的影响。
这是一项在一家三级大学附属医院的精子库进行的前瞻性队列研究。所有精子供体都反复捐献精子，并比较了接种 SARS-CoV-2 疫苗前后的平均精子参数。每位供体都作为自己的对照。对于所有参与者，在完成第二次疫苗接种后至少有一个精子样本在 72 天内被接收。主要观察指标包括总精子数、总活动精子数和活动精子百分比。
共分析了 33 名接受辉瑞 BNT162b mRNA SARS-CoV-2 病毒疫苗接种的精子供体的 898 份精子样本，其中 425 份样本在疫苗接种前接收，473 份样本在疫苗接种后接收。与接种疫苗前的样本相比，第二次疫苗接种后总精子数和总活动精子数增加。活动精子的百分比在接种疫苗后没有变化。
辉瑞 BNT162b SARS-CoV-2 疫苗对精子质量没有不良影响。应相应地向患者和医生提供咨询。
