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Qual Life Res. 2021 Dec;30(12):3367-3381. doi: 10.1007/s11136-021-02908-z. Epub 2021 Jun 19.
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Post-COVID-19 Syndrome? New daily persistent headache in the aftermath of COVID-19.新冠后综合征?新冠疫情后的新发性每日持续性头痛。
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使用 EuroQol-5D-5L 量表评估新冠后健康状况。

Evaluation of post-COVID health status using the EuroQol-5D-5L scale.

机构信息

KVG Medical College and Hospital, Sullia, India.

Department of Community Medicine, Kasturba Medical College and Hospital, Mangalore, India.

出版信息

Pathog Glob Health. 2022 Dec;116(8):498-508. doi: 10.1080/20477724.2022.2035623. Epub 2022 Feb 7.

DOI:10.1080/20477724.2022.2035623
PMID:35129097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9639560/
Abstract

SARS-CoV-2 has had a lasting effect on the overall health of recovered patients, called 'long COVID'. Currently, there is a lack of a validated standard questionnaire to assess post-COVID health status. A retrospective observational study involving the recovered COVID patients admitted to a secondary care hospital in India between June to December 2020 (n = 123), was conducted using the EuroQol-5D-5L scale at discharge, 4 weeks and 8 weeks post-discharge. A significant difference in anxiety/depression scores was found (χ = 65.6, p < 0.000) among the 3 categories of time (discharge, 4 weeks and 8 weeks). The anxiety/depression dimension scores showed a significant change (p < 0.0001) between discharge and 8 weeks, using paired t-test. Age had a significant relationship with the anxiety/depression dimension at 4 weeks (OR = 5.617, 95% CI = 1.0320-30.5746, p < 0.05). A significant difference was found using Kruskal-Wallis rank-sum test on mean index scores (χ = 60.0, p < 0.000) among the three categories of time (discharge, 4 weeks and 8 weeks). There was a statistically significant difference of time on EQ Index scores as determined by one-way repeated measures ANOVA ((2,375) = 18.941, = <0.00001). Our study found time to have a statistically significant impact on the mean index scores, level sum scores and dimension scores. Smoking was found to be significantly associated with usual activity scores at 4 weeks. The most remarkable changes occurred in the anxiety/depression dimension. Overall, there was a general trend of health improvement.

摘要

SARS-CoV-2 对康复患者的整体健康产生了持久影响,称为“长新冠”。目前,缺乏评估新冠后健康状况的经过验证的标准问卷。本回顾性观察研究纳入了 2020 年 6 月至 12 月期间在印度一家二级保健医院接受治疗的新冠康复患者(n=123),在出院时、出院后 4 周和 8 周使用欧洲五维健康量表(EQ-5D-5L)进行评估。在 3 个时间类别(出院、4 周和 8 周)中,焦虑/抑郁评分存在显著差异(χ=65.6,p<0.000)。使用配对 t 检验,在出院和 8 周之间,焦虑/抑郁维度评分显示出显著变化(p<0.0001)。年龄与 4 周时的焦虑/抑郁维度有显著关系(OR=5.617,95%CI=1.0320-30.5746,p<0.05)。在 Kruskal-Wallis 秩和检验中,3 个时间类别(出院、4 周和 8 周)的平均指数评分存在显著差异(χ=60.0,p<0.000)。通过单因素重复测量方差分析,EQ 指数评分的时间有统计学意义((2,375)=18.941,p<0.00001)。我们的研究发现时间对平均指数评分、等级和维度评分有统计学意义。在 4 周时,吸烟与日常活动评分显著相关。最显著的变化发生在焦虑/抑郁维度。总体而言,健康状况呈普遍改善趋势。