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具有过氧化物酶样活性的 Pt-Ru 双金属纳米簇用于抗菌治疗。

Pt-Ru bimetallic nanoclusters with peroxidase-like activity for antibacterial therapy.

机构信息

Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao, China.

School of Medicine, Shanghai University, Shanghai, China.

出版信息

PLoS One. 2024 May 21;19(5):e0301358. doi: 10.1371/journal.pone.0301358. eCollection 2024.

DOI:10.1371/journal.pone.0301358
PMID:38771804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11108137/
Abstract

Drug-resistant bacteria arising from antibiotic abuse infections have always been a serious threat to human health. Killing bacteria with toxic reactive oxygen species (ROS) is an ideal antibacterial method for treating drug-resistant bacterial infections. Here, we prepared Pt-Ru bimetallic nanoclusters (Pt-Ru NCs) with higher peroxidase (POD)-like activity than Pt monometallic nanoclusters. Pt-Ru can easily catalyze the decomposition of H2O2 to produce ·OH, thereby catalyzing the transformation of 3,3',5,5'-tetramethylbiphenylamine (TMB) to blue oxidized TMB (oxTMB). We utilized the POD-like activity of the Pt-Ru NCs for antibacterial therapy. The results showed that at doses of 40 μg/mL and 16 μg/mL, the Pt-Ru NCs exhibited extraordinary antibacterial activity against E. coli and S. aureus, demonstrating the enormous potential of Pt-Ru NCs as antibacterial agents.

摘要

抗生素滥用导致的耐药菌一直是人类健康的严重威胁。利用毒性活性氧（ROS）杀死细菌是治疗耐药菌感染的理想抗菌方法。在这里，我们制备了具有比 Pt 单金属纳米团簇更高过氧化物酶（POD）样活性的 Pt-Ru 双金属纳米团簇。Pt-Ru 可以很容易地催化 H2O2 的分解产生·OH，从而催化 3,3',5,5'-四甲基联苯胺（TMB）向蓝色氧化 TMB（oxTMB）的转化。我们利用 Pt-Ru NCs 的 POD 样活性进行了抗菌治疗。结果表明，在 40μg/mL 和 16μg/mL 的剂量下，Pt-Ru NCs 对大肠杆菌和金黄色葡萄球菌表现出非凡的抗菌活性，表明 Pt-Ru NCs 作为抗菌剂具有巨大的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/d8225befa666/pone.0301358.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/1b13bde4fc2c/pone.0301358.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/4d876d1acf2e/pone.0301358.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/7e68374855ff/pone.0301358.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/bdd88ffdccf1/pone.0301358.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/28480070957a/pone.0301358.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/9428dafb9807/pone.0301358.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/d8225befa666/pone.0301358.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/1b13bde4fc2c/pone.0301358.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/4d876d1acf2e/pone.0301358.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/7e68374855ff/pone.0301358.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/bdd88ffdccf1/pone.0301358.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/28480070957a/pone.0301358.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/9428dafb9807/pone.0301358.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a85/11108137/d8225befa666/pone.0301358.g007.jpg

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本文引用的文献

[1]
Stability-Based Proteomics for Investigation of Structured RNA-Protein Interactions.

Anal Chem. 2024-2-11

[2]
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ACS Nano. 2023-7-25

[3]
Tailoring the Surface and Composition of Nanozymes for Enhanced Bacterial Binding and Antibacterial Activity.

Small. 2023-10

[4]
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Adv Mater. 2024-3

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Adv Mater. 2024-3

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Small Methods. 2022-11

[7]
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Molecules. 2022-8-25

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ACS Nano. 2022-5-24

[9]
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RSC Adv. 2020-2-27

[10]
Risk Factors for Mortality Among Critical Acute Pancreatitis Patients with Carbapenem-Resistant Organism Infections and Drug Resistance of Causative Pathogens.

Infect Dis Ther. 2022-6

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