Rosenfeld S I, Waltman S R, Olk R J, Gordon M
Ophthalmology. 1986 Jan;93(1):109-15. doi: 10.1016/s0161-6420(86)33790-4.
A prospective, randomized, masked clinical study was conducted to examine the effects of pars plana vitrectomy on the corneal endothelium comparing Balanced Salt Solution (BSS) to BSS-Plus as an intraocular irrigating solution. Seventy-one patients were followed for at least six months. A significant 6.9% decrease in endothelial cell density was observed among all patients at six months postoperatively, compared to preoperative values, using the contralateral eye as a control. However, no significant difference in endothelial cell loss was found between BSS and BSS-Plus eyes. Both aphakic eyes and those undergoing lensectomy (with vitrectomy) showed a significantly greater reduction of endothelial cell density at six months compared to phakic eyes. No significant difference in corneal thickness was observed at six months postoperatively compared to preoperative values. For the one-year duration of our study BSS was as efficacious in preserving the integrity of the corneal endothelium as was BSS-Plus.
进行了一项前瞻性、随机、双盲临床研究，以比较平衡盐溶液（BSS）和BSS-Plus作为眼内冲洗液时，玻璃体切除术对角膜内皮的影响。71例患者随访至少6个月。以对侧眼作为对照，术后6个月时，所有患者的内皮细胞密度与术前相比显著下降了6.9%。然而，BSS组和BSS-Plus组的内皮细胞丢失无显著差异。与有晶状体眼相比，无晶状体眼和接受晶状体切除术（联合玻璃体切除术）的患者在术后6个月时内皮细胞密度的降低更为显著。术后6个月时，角膜厚度与术前相比无显著差异。在我们为期一年的研究中，BSS在维持角膜内皮完整性方面与BSS-Plus同样有效。
