Rodrigues Oliveira Ayisa, Oliveira Dos Santos Daniel, Pizzolato de Lucena Fabiana, Aquino de Mattos Sara, Parente de Carvalho Thaynara, Barroso Costa Fabíola, Giannini Alves Moreira Larissa, Magalhães Arthuso Vasconcelos Izabela, Alves da Paixão Tatiane, Lima Santos Renato
Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Instituto Municipal de Medicina Veterinária Jorge Vaitsman, Rio de Janeiro, Brazil.
Vet Pathol. 2022 May;59(3):482-488. doi: 10.1177/03009858221075595. Epub 2022 Feb 7.
From 2016 to 2019, Southeastern Brazil faced an outbreak of yellow fever (YF) affecting both humans and New World primates (NWP). The outbreak was associated with a marked increase in traumatic lesions in NWP in the affected regions. Non-thrombotic pulmonary embolization (NTPE) can be a consequence of massive traumatic events, and it is rarely reported in human and veterinary medicine. Here, we describe NTPE of the brain, liver, and bone marrow in free-ranging NWP, highlighting the epidemiological aspects of these findings and the lesions associated with this condition, including data on traumatic injuries in wild NWP populations during the course of a recent YF outbreak. A total of 1078 NWP were necropsied from January 2017 to July 2019. Gross traumatic injuries were observed in 444 marmosets (44.3%), 10 howler monkeys (23.2%), 9 capuchins (31.0%), 1 titi-monkey (50.0%), and 1 golden lion tamarin (33.3%). NTPE was observed in 10 animals, including 9 marmosets (2.0%) and 1 howler monkey (10.0%). NTPE was identified in the lung and comprised hepatic tissue in 1 case, brain tissue in 1 case, and bone marrow tissue in 8 cases. Although uncommon, it is important to consider NTPE with pulmonary vascular occlusion during the critical care of traumatized NWP. In addition, this study highlights the importance of conservational strategies and environmental education focusing on One Health, not only to protect these free-ranging NWP populations but also to maintain the efficacy of epidemiological surveillance programs.
2016年至2019年，巴西东南部面临黄热病（YF）疫情，人类和新大陆灵长类动物（NWP）均受影响。此次疫情与受影响地区NWP创伤性损伤的显著增加有关。非血栓性肺栓塞（NTPE）可能是大规模创伤事件的后果，在人类和兽医学中鲜有报道。在此，我们描述了自由放养的NWP中脑、肝和骨髓的NTPE，强调了这些发现的流行病学方面以及与此病症相关的病变，包括近期黄热病疫情期间野生NWP种群创伤性损伤的数据。2017年1月至2019年7月，共对1078只NWP进行了尸检。在444只狨猴（44.3%）、10只吼猴（23.2%）、9只卷尾猴（31.0%）、1只伶猴（50.0%）和1只金狮狨（33.3%）中观察到明显的创伤性损伤。在10只动物中观察到NTPE，包括9只狨猴（2.0%）和1只吼猴（10.0%）。NTPE在肺中被发现，其中1例包含肝组织，1例包含脑组织，8例包含骨髓组织。尽管不常见，但在对受创伤的NWP进行重症护理时，考虑伴有肺血管阻塞的NTPE很重要。此外，本研究强调了以“同一健康”为重点的保护策略和环境教育的重要性，这不仅是为了保护这些自由放养的NWP种群，也是为了维持流行病学监测计划的有效性。
