Centro de Patologia, Instituto Adolfo Lutz, Avenida Dr. Arnaldo, 351, Pacaembú, São Paulo, SP, 01246000, Brazil.
Programa de Pós-Graduação Em Doenças Infecciosas E Parasitárias - Faculdade de Medicina, Universidade Federal de Mato Grosso Do Sul, Bairro Universitário, Av. Costa E Silva, S/nº, Campo Grande, MS, 79070900, Brazil.
Braz J Microbiol. 2023 Dec;54(4):3201-3209. doi: 10.1007/s42770-023-01105-z. Epub 2023 Sep 9.
Transmission of herpesvirus between humans and non-human primates represents a serious potential threat to human health and endangered species conservation. This study aimed to identify herpesvirus genomes in samples of neotropical primates (NTPs) in the state of São Paulo, Brazil. A total of 242 NTPs, including Callithrix sp., Alouatta sp., Sapajus sp., and Callicebus sp., were evaluated by pan-herpesvirus polymerase chain reaction (PCR) and sequencing. Sixty-two (25.6%) samples containing genome segments representative of members of the family Herpesviridae, including 16.1% for Callitrichine gammaherpesvirus 3, 6.1% for Human alphaherpesvirus 1, 2.1% for Alouatta macconnelli cytomegalovirus, and 0.83% for Cebus albifrons lymphocryptovirus 1. No co-infections were detected. The detection of herpesvirus genomes was significantly higher among adult animals (p = 0.033) and those kept under human care (p = 0.008671). These findings confirm the importance of monitoring the occurrence of herpesviruses in NTP populations in epizootic events.
人类与非人类灵长类动物之间的疱疹病毒传播对人类健康和濒危物种保护构成了严重的潜在威胁。本研究旨在鉴定巴西圣保罗州新热带灵长类动物（NTP）样本中的疱疹病毒基因组。通过 pan-herpesvirus 聚合酶链反应（PCR）和测序，对包括 Callithrix sp.、Alouatta sp.、Sapajus sp. 和 Callicebus sp. 在内的 242 只 NTP 进行了评估。62 个（25.6%）样本含有疱疹病毒科成员的基因组片段，包括 16.1%的 Callitrichine gammaherpesvirus 3、6.1%的 Human alphaherpesvirus 1、2.1%的 Alouatta macconnelli cytomegalovirus 和 0.83%的 Cebus albifrons lymphocryptovirus 1。未检测到合并感染。疱疹病毒基因组的检测在成年动物（p = 0.033）和受人类照顾的动物（p = 0.008671）中显著更高。这些发现证实了在 NTP 种群中监测疱疹病毒发生的重要性，以应对疫病事件。
