Hulshof J H, Vermeij P
ORL J Otorhinolaryngol Relat Spec. 1986;48(1):33-6. doi: 10.1159/000275839.
The suppressive effect of flunarizine on tinnitus was assessed in a double-blind trial in 50 patients with tinnitus due to various causes. The duration of the study was 6 weeks. Serum levels of the drug were determined. The patient's subjective assessment of the effect was taken as criterion for the evaluation; objective tests were found to be unsuitable for this purpose. Ten of the patients suffered from dizziness as a secondary complaint. For the group as a whole, there was no difference between flunarizine and the placebo with respect to the effect on tinnitus, but in the 10 patients with dizziness as well there was a significant difference in favor of the drug. Conclusions cannot be drawn as to the reason for this divergence, because the number of patients was too small.
在一项双盲试验中，对50例因各种原因导致耳鸣的患者评估了氟桂利嗪对耳鸣的抑制作用。研究持续时间为6周。测定了药物的血清水平。以患者对疗效的主观评估作为评价标准；发现客观测试不适用于此目的。10例患者伴有头晕这一继发症状。对于整个组而言，氟桂利嗪和安慰剂在对耳鸣的疗效方面没有差异，但在10例伴有头晕的患者中，该药显示出显著疗效。由于患者数量过少，无法就此差异的原因得出结论。
