Department of Laboratory Medicine, The Second People's Hospital of Lianyungang, Lianyungang, China.
Department of Endocrinology, The Second People's Hospital of Lianyungang, Lianyungang, China.
J Clin Lab Anal. 2022 Mar;36(3):e24283. doi: 10.1002/jcla.24283. Epub 2022 Feb 8.
The present study investigated the relationships between serum amyloid A (SAA), 25-hydroxyvitamin D (25(OH)VD) and diabetic nephropathy (DN) to provide evidence for the prevention and management of DN.
A total of 182 patients with type 2 diabetes mellitus (T2DM) were enrolled in this study. The levels of SAA, 25(OH)VD, and other conventional indicators were measured and analyzed. Receiver operating characteristic curve analysis was applied for the combined measurement of SAA and 25(OH)VD, and risk factors for DN were evaluated using binary logistic regression analysis.
The levels of SAA in T2DM patients were significantly higher than those in healthy subjects, and the level significantly increased with the progression of DN (p < 0.05). In contrast, the level of 25(OH)VD in T2DM patients was significantly lower than that in healthy subjects, and the level significantly decreased with the progression of DN (p < 0.05). The combined measurement of SAA and 25(OH)VD distinguished DN patients from T2DM patients better than the measurement of SAA or 25(OH)VD alone. SAA was an independent risk factor for DN, and 25(OH)VD was an independent protective factor for DN.
SAA and 25(OH)VD might be used as potential markers to identify patients at increased risk of developing DN.
本研究旨在探讨血清淀粉样蛋白 A（SAA）、25-羟维生素 D（25（OH）VD）与糖尿病肾病（DN）的关系，为 DN 的防治提供依据。
纳入 182 例 2 型糖尿病患者，检测并分析 SAA、25（OH）VD 等常规指标。应用受试者工作特征曲线分析 SAA 与 25（OH）VD 的联合检测，采用二元 logistic 回归分析评估 DN 的危险因素。
T2DM 患者的 SAA 水平明显高于健康人群，且随着 DN 的进展逐渐升高（p<0.05）。相反，T2DM 患者的 25（OH）VD 水平明显低于健康人群，且随着 DN 的进展逐渐降低（p<0.05）。SAA 与 25（OH）VD 的联合检测对 DN 患者的区分能力优于 SAA 或 25（OH）VD 的单项检测。SAA 是 DN 的独立危险因素，25（OH）VD 是 DN 的独立保护因素。
SAA 和 25（OH）VD 可作为潜在的标志物，用于识别易发生 DN 的患者。
