Refractories, Ceramics and Building Materials Department, Advanced Materials, Technology and Mineral Resources Research Institute, National Research Centre, 33 El Bohouth St., Dokki, PO Box 12622 Cairo, Egypt.
Refractories, Ceramics and Building Materials Department, Advanced Materials, Technology and Mineral Resources Research Institute, National Research Centre, 33 El Bohouth St., Dokki, PO Box 12622 Cairo, Egypt.
Int J Pharm. 2022 Mar 25;616:121559. doi: 10.1016/j.ijpharm.2022.121559. Epub 2022 Feb 5.
Metal organic framework (MOF)-nanocages (MOF-NCs) in the form of zinc-based nanoparticles (NPs) were synthesized as drug carriers for the purpose of wound healing. The prepared NCs (single and bi-metallic with silver-MOF) were based on zinc and they were loaded with ascorbic acid (vitamin C) as a model drug which accelerates wound healing. The NCs were then investigated by several characterization techniques such as XRD, TEM, FTIR and BET surface area. Furthermore, the release behavior of the loaded ascorbic acid from the developed NCs was measured in phosphate buffer solution (PBS). NCs antibacterial activity was tested against strain of gram-positive bacteria (Staphylococcus aureus ATCC- 29213, Streptococcus pyogenes ATCC-19615 and Bacillus subtilis ATCC-6633), gram-negative bacteria strain (Pseudomonas aeruginosaATCC-27853and Escherichia coli ATCC-25922) and fungi (Candida albicans ATCC-10231).The physicochemical features of the NCs were confirmed by the results obtained from XRD and FTIR measurements. The particle size of the NCs was confirmed to be in the range of 30-50 nm. Prolonged drug release that was combined with impressive antibacterial activities, and good wound healing rates were also recognized for the zinc based NCs in comparison to commonly used Ag NPs. It is concluded that the current NCs are potentially suitable for wound healing and drug delivery applications.
金属有机骨架（MOF）-纳米笼（MOF-NC）以锌基纳米颗粒（NPs）的形式被合成，作为药物载体用于伤口愈合。所制备的 NC（单金属和双金属的银-MOF）基于锌，并负载抗坏血酸（维生素 C）作为促进伤口愈合的模型药物。然后通过 XRD、TEM、FTIR 和 BET 表面积等多种表征技术对 NC 进行了研究。此外，还在磷酸盐缓冲溶液（PBS）中测量了开发的 NC 中负载的抗坏血酸的释放行为。NC 的抗菌活性针对革兰氏阳性菌（金黄色葡萄球菌 ATCC-29213、化脓性链球菌 ATCC-19615 和枯草芽孢杆菌 ATCC-6633）、革兰氏阴性菌（铜绿假单胞菌 ATCC-27853 和大肠杆菌 ATCC-25922）和真菌（白色念珠菌 ATCC-10231）进行了测试。NC 的物理化学特性通过 XRD 和 FTIR 测量结果得到证实。NC 的粒径被确认为 30-50nm 范围内。与常用的 Ag NPs 相比，锌基 NC 还具有令人印象深刻的延长药物释放、良好的伤口愈合率和抗菌活性。可以得出结论，目前的 NC 很可能适用于伤口愈合和药物输送应用。
