College of Materials Science and Engineering, Institute for Graphene Applied Technology Innovation, Laboratory of Fiber Materials and Modern Textiles, Growing Base for State Key Laboratory, Collaborative Innovation Center for Marine Biomass Fibers Materials and Textiles of Shandong Province , Qingdao University , Qingdao 266071 , China.
ACS Appl Mater Interfaces. 2019 May 15;11(19):17177-17183. doi: 10.1021/acsami.9b01149. Epub 2019 Apr 30.
Because of the abuse of antibiotics and threats of antibiotic resistance, bacterial infection is still one of the most difficult issues to be resolved. Thus, it is of great significance to explore novel antibacterial agents. In this paper, we investigated a type of silica-coated gold-silver nanocages (Au-Ag@SiO NCs) as antibacterial candidates. Their intrinsic characteristics of photothermal property and sustained release of Ag ions were fully exploited for near-infrared (NIR)-induced combined anti-infective therapy. The broad-spectrum antibacterial property of the as-prepared Au-Ag@SiO NCs was confirmed in vitro against Gram-positive Staphylococcus aureus ( S. aureus) and Gram-negative bacteria Escherichia coli ( E. coli). In addition, Au-Ag@SiO NCs exhibit effective treatment of the S. aureus biofilm with the assistance of NIR irradiation. More importantly, we assessed the in vivo antibacterial efficacy of Au-Ag@SiO NCs against S. aureus, which demonstrated sustainably enhanced therapeutic effects on a rat model with wound infection.
由于抗生素的滥用和抗生素耐药性的威胁，细菌感染仍然是最难解决的问题之一。因此，探索新型抗菌剂具有重要意义。本文研究了一种二氧化硅包覆的金银纳米笼（Au-Ag@SiO2 NCs）作为抗菌候选物。充分利用其光热特性和银离子的持续释放，实现了近红外（NIR）诱导的联合抗感染治疗。体外实验证实了所制备的 Au-Ag@SiO2 NCs 对革兰氏阳性金黄色葡萄球菌（S. aureus）和革兰氏阴性大肠杆菌（E. coli）的广谱抗菌性能。此外，在近红外照射的辅助下，Au-Ag@SiO2 NCs 对金黄色葡萄球菌生物膜表现出有效的治疗作用。更重要的是，我们评估了 Au-Ag@SiO2 NCs 在金黄色葡萄球菌感染的大鼠模型中的体内抗菌疗效，结果表明其对感染伤口具有持续增强的治疗效果。
