Hagerman R J, Jackson A W, Levitas A, Braden M, McBogg P, Kemper M, McGavran L, Berry R, Matus I, Hagerman P J
Am J Med Genet. 1986 Jan-Feb;23(1-2):241-62. doi: 10.1002/ajmg.1320230119.
A double-blind, crossover study of a 10 mg folic acid per day (vs. placebo) treatment was carried out in 25 fra(X) males (ages 1-31 years). Each treatment period lasted 6 months. Before, during and after the study, the patients were assessed blindly with psychological, language and behavioral evaluations, and parent or caretaker reports were collected. Standardized testing did not show statistically significant changes in the group as a whole; psychological testing demonstrated a statistically significant improvement on folic acid in the prepubertal males. After uncoding, caretaker or parent reports also demonstrated behavioral improvements in the prepubertal males while being treated with folic acid.
对25名脆性X综合征男性患者（年龄1至31岁）进行了一项双盲交叉研究，比较每日服用10毫克叶酸（与安慰剂相比）的治疗效果。每个治疗期持续6个月。在研究前、研究期间和研究后，对患者进行了心理、语言和行为评估的盲法评估，并收集了家长或照顾者的报告。标准化测试未显示整个组有统计学上的显著变化；心理测试表明，青春期前男性服用叶酸后有统计学上的显著改善。在解除编码后，家长或照顾者的报告也表明，青春期前男性在服用叶酸治疗期间行为有所改善。
