Madison L S, Wells T E, Fristo T E, Benesch C G
J Dev Behav Pediatr. 1986 Aug;7(4):253-6. doi: 10.1097/00004703-198608000-00007.
Three fragile X syndrome males were given 10 mg folic acid daily in a multiple-baseline, placebo study. Objective measures of memory skills, compliance, and behavioral appropriateness were taken during baseline, placebo, and treatment conditions. No change was evident in these variables during the drug trial. Thus, the findings shed doubt on the effectiveness of folic acid in increasing intellectual functioning or reducing behavior problems in individuals with fragile X syndrome. These results underscore the importance of operationally defined variables, double-blind observation and placebo treatment in elucidating the effects of folic acid.
在一项多基线、安慰剂对照研究中，三名脆性X综合征男性患者每天服用10毫克叶酸。在基线期、安慰剂期和治疗期，对记忆技能、依从性和行为适宜性进行了客观测量。在药物试验期间，这些变量没有明显变化。因此，这些研究结果对叶酸在提高脆性X综合征患者智力功能或减少行为问题方面的有效性提出了质疑。这些结果强调了在阐明叶酸作用时，操作定义变量、双盲观察和安慰剂治疗的重要性。
