高剂量叶酸治疗脆性X男性患者。

High dose folic acid treatment of fragile (X) males.

作者信息

Brown W T, Cohen I L, Fisch G S, Wolf-Schein E G, Jenkins V A, Malik M N, Jenkins E C

出版信息

Am J Med Genet. 1986 Jan-Feb;23(1-2):263-71. doi: 10.1002/ajmg.1320230120.

DOI:10.1002/ajmg.1320230120

Abstract

We conducted an experimental trial of high-dose folic acid given to five males, ages 8 to 26 years, with the fra(X) syndrome. In this double blind study, each subject received 250 mg per day of folic acid for 3 months, followed by placebo for 3 months, and folic acid again for an additional three months. Based on IQ tests, behavior ratings, the Autistic Descriptors Checklist, and parental ratings, there was little evidence to suggest any positive effects seen during the administration of high-dose folic acid. Therefore, this study has provided little support for a hypothesis of benefit of high-dose folic acid in the treatment of the fra(X) syndrome.

摘要

我们对5名年龄在8至26岁之间患有脆性X综合征的男性进行了高剂量叶酸的实验性试验。在这项双盲研究中，每位受试者每天服用250毫克叶酸，持续3个月，随后服用3个月安慰剂，然后再服用3个月叶酸。根据智商测试、行为评分、自闭症描述清单和家长评分，几乎没有证据表明在高剂量叶酸给药期间有任何积极效果。因此，本研究几乎没有支持高剂量叶酸治疗脆性X综合征有益的假设。