Gillberg C, Wahlström J, Johansson R, Törnblom M, Albertsson-Wikland K
Dev Med Child Neurol. 1986 Oct;28(5):624-7. doi: 10.1111/j.1469-8749.1986.tb03905.x.
Four boys with the combination of infantile autism and the fragile-X syndrome were given oral folic acid and placebo, according to a double-blind crossover design. One boy's behaviour appeared to improve on folic acid, but another boy did not seem to be affected at all. For the remaining two boys the results were equivocal. Further study of folic acid in the treatment of autistic boys with the fragile-X syndrome is warranted.
根据双盲交叉设计，对四名患有婴儿自闭症和脆性X综合征的男孩给予口服叶酸和安慰剂。一名男孩服用叶酸后行为似乎有所改善，但另一名男孩似乎完全没有受到影响。对于其余两名男孩，结果不明确。有必要对叶酸治疗患有脆性X综合征的自闭症男孩进行进一步研究。
